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Application of nanometer montmorillonite for pharmaceutical use, and medicine compositions therewith

A nano-montmorillonite and composition technology, which is applied in the field of nano-montmorillonite, can solve the problems of not finding a treatment method for reversing the action of chronic atrophic gastritis, not finding a treatment method for chronic atrophic gastritis, etc., so as to improve medical use, strengthen Medical use, fine particle effect

Active Publication Date: 2007-07-25
ZHEJIANG HAILISHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no treatment that can effectively block chronic atrophic gastritis, let alone a treatment that can reverse chronic atrophic gastritis.

Method used

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  • Application of nanometer montmorillonite for pharmaceutical use, and medicine compositions therewith
  • Application of nanometer montmorillonite for pharmaceutical use, and medicine compositions therewith

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of nano-montmorillonite

[0027] (1) Add 20g of n-butyl titanate, 40g of distilled water, 40g of hydrochloric acid, and 50g of ethanol into the container, and stir and react at normal pressure and 45°C for 5 hours to obtain a glue solution; (2) Add 10g of montmorillonite powder Raw material (its specific surface area is 69.8782m 2 / g(BET) or 106.6111m 2 / g (Langmuir)) was added to the glue solution obtained in step (1), under the conditions of temperature 50°C and normal pressure, the reaction was stirred for 4 hours, and the specific surface area of ​​the obtained nano-montmorillonite after filtration, separation, washing and drying was 243.9978m 2 / g(BET) or 407.2757m 2 / g (Langmuir).

Embodiment 2

[0028] Example 2 Preparation of nano-montmorillonite

[0029] (1) Add 15g of n-butyl titanate, 45g of distilled water, 40g of hydrochloric acid, and 60g of ethanol into the container, stir and react under normal pressure for 4 hours, and control the temperature at 45°C to prepare the glue; (2) Add 6g of montmorillonite Stone powder raw material (its specific surface area is 69.8782m 2 / g(BET) or 106.6111m 2 / g (Langmuir)) was added to the glue solution obtained in step (1), under normal pressure and 50°C, stirred and reacted for 6 hours, filtered, separated, washed, dried, sterilized and activated by microwave to obtain the product. The specific surface area of ​​the obtained nano-montmorillonite is 241.7658m 2 / g(BET) or 405.4369m 2 / g (Langmuir), its medicinal effect is 3 times that of ordinary montmorillonite, which can greatly reduce the dosage of medicine used by patients.

[0030] In the following, the efficacy test example will be used to verify the reverse therap...

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Abstract

An application of the montmorillonite nanoparticles in preparing the medicine for treating the ulcer in digestive tract, regurgitation of stomach and esophagus, esophagitis, gastritis, colitis, acute diarrhea, chronic atrophic gastritis is disclosed. Its composite medicine is also disclosed.

Description

technical field [0001] The invention relates to the use of nanometer montmorillonite, in particular to the application of nanometer montmorillonite in the pharmaceutical field and its pharmaceutical composition. Background technique [0002] Montmorillonite is a layered aluminosilicate mineral containing water, and its structural unit is a monoclinic system consisting of two layers of silicon-oxygen tetrahedron sandwiching a layer of aluminum-oxygen octahedron. Due to the special structure of montmorillonite, it has many excellent properties, such as swelling, dispersibility, cation exchange, suspension, non-toxicity, stability, adsorption and so on. The high specific surface area and strong adsorption of montmorillonite make it widely used in industry and medicine. Many articles have reported the preparation of nano-montmorillonite by intercalation to increase its specific surface area. For example, Chinese patent 99119653.8 discloses a method for preparing nanocomposites ...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61P1/04A61P1/12A61P5/16A61P13/12A61P1/02A61P17/00A61P25/32
Inventor 郑海辉
Owner ZHEJIANG HAILISHENG PHARM CO LTD
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