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Antineoplastic alkaloid

A technology for anti-tumor drugs and alkaloids, which can be used in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., and can solve problems such as unsatisfactory

Inactive Publication Date: 2007-08-08
朱峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antineoplastic drugs have been able to cure or control many tumor types, but the overall level has not yet reached a satisfactory stage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] The antineoplastic drug alkaloid of the present invention is 1-isoquinolinone alkaloids, which are two kinds of compound A and compound B, which are based on "Science Bulletin", 2006, volume 51, phase 7, page 792-795] literature [two Strain South China Sea mangrove endophytic fungus mixed fermentation produces new alkaloid marinamide and its methyl ester] described preparation method, that is: use GYP as medium to mix and ferment and cultivate two strains of marine fungi (the strain numbers are №1924 and №3893, the bacteria The silk is soaked and extracted with ethanol, and the extract is prepared by silica gel column chromatography, eluted with ethyl acetate and then eluted with 9:1 ethyl acetate-methanol.

[0014] The MTT reduction method detects compound A and compound B antitumor activity test as follows;

[0015] 1).Material:

[0016] 1). 1DMEM / F12 (DF12) medium, trypsin, newborn calf serum, DMSO; after compound A and compound B are dissolved in DMSO, dilute to th...

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Abstract

The invention discloses an antineoplastic alkaloid with structural formula as right formula, which possesses obvious antineoplastic activity.

Description

technical field [0001] The invention relates to the preparation of antitumor drugs, in particular to alkaloids with antitumor effects. Background technique [0002] Malignant tumor is a disease that seriously endangers human life. Its mortality rate is second only to cardiovascular and cerebrovascular diseases, and its incidence is increasing year by year. Now there are surgery, radiotherapy and drug therapy methods for tumor treatment, among which drug therapy has positive, positive and irreplaceable effects in tumor treatment or comprehensive treatment, prolonging the life of tumor patients and improving their quality of life. Antineoplastic drugs have been able to cure or control many tumor types, but the overall level has not yet reached a satisfactory stage. Therefore, it is of great significance to research and develop drugs with effective antitumor activity. Obtaining active ingredients from natural plants and using them as lead compounds is one of the important way...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/04A61K31/4709A61P35/00
Inventor 朱峰陈光英林永成罗景慧
Owner 朱峰
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