Methods for treating bone cancer pain by administering a nerve growth factor antagonist
A nerve growth factor, antagonist technology, applied in the direction of anti-growth factor immunoglobulin, anti-animal/human immunoglobulin, antibody, etc., can solve problems such as pain and increased pain sensitivity
Active Publication Date: 2010-12-01
RINAT NEUROSCI CORP +1
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Treatment with exogenous NGF results in increased pain and pain sensitivity
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Abstract
The invention provides methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.
Description
Methods of treating bone cancer pain by administering nerve growth factor antagonists Cross references to related applications This application claims priority to U.S. Provisional Patent Application Serial Nos. 60 / 620,654, filed October 19, 1994, and 60 / 560,781, filed April 7, 2004, all of which are hereby incorporated in their entirety Reference. Statement Regarding Federally Funded Research or Development This invention was made with US Government support under National Institutes of Health grant numbers 5R37-NS23970-16, 5R01-DA11986-05, and 1R01-NS048021-01A1. The US Government has certain rights in this invention. field of invention The invention relates to the use of a nerve growth factor (NGF) antagonist for the prevention, improvement or treatment of bone cancer pain. Background of the invention Nerve growth factor (NGF) was the first identified neurotrophin and its role in the development and survival of peripheral and central neurons has been well characte...
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IPC IPC(8): C07K16/22A61K39/395
Inventor D・L・谢尔顿P・W・门蒂
Owner RINAT NEUROSCI CORP
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