Pharmaceutical composition containing arctigenin and preparation method

A technology of arctigenin and composition, which is applied in emulsion and its preparation, and the field of medicinal composition and preparation of arctigenin, can solve the problems of injection administration limitation, undiscovered report, etc.

Inactive Publication Date: 2007-09-19
海南盛科天然药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Because arctigenin is a fat-soluble compound, its preparation application, especially injection administration, is limited, and no related reports have been found

Method used

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  • Pharmaceutical composition containing arctigenin and preparation method

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0021] Preparation Example 1: Preparation of Arctiin

[0022] The burdock fruit is ground into a coarse powder, extracted with petroleum ether, ethyl acetate and 80% ethanol in sequence, and the solvent is recovered separately, and the ethanol extract is taken. Adjust this extract to a certain volume with water, extract with n-butanol, reclaim n-butanol to obtain n-butanol extract, take the above-mentioned n-butanol extract dry paste, and carry out macroporous adsorption resin column chromatography (dry paste and The resin ratio is 1:30). First wash with water until the eluent is colorless, then use 30% ethanol to elute until the solution is colorless, recover the ethanol, concentrate and stand still, and then gray-white powder particles appear. The off-white powder was passed through a silica gel H decompression column (dry packing), eluted with chloroform-methanol (9:1), and after the solvent was recovered, pure white crystals were obtained which were arctiin, and the purit...

preparation example 2

[0023] Preparation Example 2: Preparation of Arctigenin

[0024] Add arctiin from Preparation Example 1 into sterile water, heat to dissolve, let cool, add an appropriate amount of helicase, incubate on a constant temperature shaker at 37°C for 36 hours, add ethanol to stop the enzymatic hydrolysis reaction, evaporate the enzymolysis solution to dryness under reduced pressure, and the residue Add chloroform to dissolve, take the chloroform solution, recover the solvent to obtain the degraded product, pass the obtained degraded product through a silica gel H decompression column (dry packing), and elute with a gradient of chloroform-methanol, and after recovering the solvent, a pure white crystal is obtained, which is burdock Aglycone, the purity measured by HPLC method is 98.2%.

preparation example 3

[0025] Preparation Example 3: Preparation of Blank Emulsion

[0026] Add 1.2g of egg yolk phospholipids to 10g of refined soybean oil, add 0.1g of oleic acid, heat to 60-80°C, stir to dissolve into a clear solution, and obtain an oil phase; dissolve 2.25g of glycerin in 60ml of water to form Water phase, heated to 60-80°C; add the oil phase to the water phase and emulsify into colostrum with high-speed stirring, add water to the volume of the colostrum to 100ml, emulsify under the condition of a pressure of 100Mpa by a high-pressure homogenizer, After subpackaging, it was sterilized at 121°C for 15 minutes to prepare an emulsion. The obtained emulsion is a homogeneous emulsion with an average particle diameter of 168nm.

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Abstract

A composition for medicine having arctigenin and a method for preparing the same. The composition includes arctigeni, oil, emulsifier and water which is capable of producing emulsion for oral taking and intravenous.

Description

technical field [0001] The invention relates to a medicinal composition of arctigenin, specifically a medicinal composition and a preparation method of arctigenin, such as an emulsion and preparation thereof. Background technique [0002] Arctium lappa L. is a plant of the genus Arctium of Compositae, and its seeds, roots and leaves can be used as medicine. The commonly used medicinal part of burdock is its fruit, which is called burdock seed. Its taste is hard and cold. It has the effects of evacuating wind-heat, clearing the lungs and clearing the rash, reducing swelling and detoxification, and is used for wind-heat and cold, cough with excessive phlegm, sore throat, opaque rash, itchy rubella, carbuncle and sore. Burdock mainly contains lignans and their glycosides. There are many types of lignans found in nature, and recent studies have shown that the physiological and pharmacological activities of lignans with different structural types are not the same. The lignans...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/107A61K47/44A61P31/12A61P29/00A61P35/00A61P37/02A61P3/10
Inventor 滕厚雷于翠翠韩飞翟大伟刘军锋邵萌
Owner 海南盛科天然药物研究院有限公司
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