Oil-in-water type nanometer emulsion elecampane oil and litsea citrata oil and the method for preparing the same

A technology of cypress seed oil and nano-emulsion, applied in the field of medicine, can solve the problems of irritation, poor solubility, unstable physical properties, etc., and achieve the effects of preventing the invasion of bacteria, improving the antiseptic performance, and improving the sensory quality.

Inactive Publication Date: 2007-09-19
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It also overcomes the problems of poor solubility, unstable physical properties, and irritation of woody oil and Litsea Cubelia oil, and also overcomes the difficulty of dispersing them in water, so that higher drug efficacy can be obtained at low dosages, improving the Patient compliance, so that the therapeutic effect of woody oil and Litsea columba oil can be brought into full play

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] 1) Prepare the nanoemulsion with the selected oil phase and surfactant according to the mass ratio of 9:1 to 1:9 by calculating the HLB value, and draw the pseudo-ternary phase diagram to determine the optimal ratio of each component.

[0063] 2) Weigh 2.25g of polyoxyethylene ether (40) hydrogenated castor oil (RH-40), 0.25g of isopropyl myristate (IPM), 0.10g of woody oil, 0.10g of Litsea chinensis oil and 5.30g of distilled water for later use .

[0064] 3) Mix the surfactant polyoxyethylene ether (40) hydrogenated castor oil (RH-40) and the oil phase isopropyl myristate (IPM) at room temperature at 25°C, and stir continuously to make it fully mixed; then Add woody oil and Litsea coccinosa oil, stir well, slowly add distilled water to it, and stir while adding water; the viscosity of the system is small at the beginning, as the amount of distilled water increases, the system will become viscous, and liquid crystals may appear in the system at this time State or wate...

Embodiment 2

[0066] 1) Prepare the nanoemulsion with the selected oil phase and surfactant according to the mass ratio of 9:1 to 1:9 by calculating the HLB value, and draw the pseudo-ternary phase diagram to determine the optimal ratio of each component.

[0067] 2) Weigh 2.25g of castor oil polyoxyethylene ether-40 (EL-40), 0.25g of isopropyl myristate (IPM), 0.50g of woody oil, 0.50g of Litsea chinensis oil and 4.50g of distilled water for later use.

[0068] 3) with the operation of "step 3)" in embodiment 1

Embodiment 3

[0070] 1) Prepare the nanoemulsion with the selected oil phase and surfactant according to the mass ratio of 9:1 to 1:9 by calculating the HLB value, and draw the pseudo-ternary phase diagram to determine the optimal ratio of each component.

[0071] 2) Weigh 2.25g of polyoxyethylene ether (40) hydrogenated castor oil (RH-40), 0.25g of isopropyl myristate (IPM), 1.00g of woody oil, 1.00g of Litsea chinensis oil and 3.50g of distilled water for later use .

[0072] 3) with the operation of "step 3)" in embodiment 1

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Abstract

The invention discloses an oil-in-water type nanometer emulsion having alantol and litsea cubeba oil, and a method for preparing the same. The invention comprises a surfactant of 15-30%, an oil phase of 2-15%, the alantol of 0.05-25%, the litsea cubeba oil of 0.05-25%, and distilled water of residuary. The oil-in-water alantol and litsea cubeba oil nanometer emulsion is yellow or achromatic transparency liquid in appearance, with diameter distribution of the liquid droplet of 1-30nm, and fine stability; can increase medicine stability of the alantol and litsea cubeba oil in the preparing process, improve solubility and bioavailability, defer the medicine metabolism time within a human body, reduce quantity of accessories and production cost, thus has abroad market prospect in medical art.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of broad-spectrum antibacterial and antiviral drugs for external use and a preparation method thereof, in particular to a transparent and stable oil-in-water type woody oil and litsea cubeba seed oil nanoemulsion and a preparation method thereof. Background technique [0002] At present, bacterial and viral infections have a high incidence rate and various types. Because of their frequent occurrence, patients not only suffer from the pain of the disease itself, but also hinder the appearance and appearance, which brings great troubles to patients. Volatile oil is an important class of active ingredients. In addition to the functions of dispersing and detoxifying, aromatherapy, regulating qi and relieving pain, expelling wind and dampness, promoting blood circulation and removing blood stasis, dispelling cold and warming the interior, clearing heat a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K9/107A61K47/34A61K47/44A61P31/04A61P31/12
Inventor 欧阳五庆李树珍
Owner NORTHWEST A & F UNIV
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