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Compound all-trans retinoic acid cream and its preparation method and application

A technology of all-trans retinoic acid and compound all-trans, which is applied in ointment delivery, pharmaceutical formula, emulsion delivery, etc., to save the time of visiting a doctor and increase the cure rate.

Inactive Publication Date: 2007-10-24
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports on the combination of ATRA and beclomethasone dipropionate in the treatment of scars at home and abroad.

Method used

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  • Compound all-trans retinoic acid cream and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Compound all-trans retinoic acid cream and weight ratio:

[0030] Urea 50g Glycerin 150g Sodium Lauryl Sulfate 3g Triethanolamine 6g Monoglyceride 20g

[0031] Stearic acid 100g white petrolatum 50g liquid paraffin 190g

[0032] Ethylparaben 1g Add distilled water to 1000g All-trans retinoic acid 0.125g Beclomide propionate

[0033] Loose 0.125g

Embodiment 2

[0035] Preparation method of compound all-trans retinoic acid cream

[0036] 1) Take 50g of urea, 150g of glycerin, 3g of sodium lauryl sulfate, 6g of triethanolamine and add distilled water to 430g as the water phase;

[0037] 2) Take 20g of monoglyceride, 100g of stearic acid, 50g of white petrolatum, 190g of liquid paraffin and 1g of ethylparaben as the oil phase;

[0038] 3) Put the two phases in separate containers, heat until melted or dissolved, and keep at 60°C, slowly add the oil phase to the water phase, add 0.125g of all-trans retinoic acid, acetone and Beclomethasone 0.125g, stir well, and get it.

Embodiment 3

[0040] Case 1: Female, 55 years old, came to our department for treatment in September 2004 with a spontaneous chest scar for 10 years, which was painful and itchy. Examination revealed a 1 cm × 0.5 cm red scar in the chest area, which was raised above the skin and had a hard texture (Fig. 1, a). After local injection of hormone drugs, the scar became flat and soft, but the scar was still congested and recurred from time to time (Fig. 1, b). From August 2005, compound all-trans retinoic acid cream was applied to the affected area once a day. After 12 months of continuous application, the scar did not recur, and the skin of the scar was transformed into normal skin (Fig. 1, c) .

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Abstract

The invention relates to a compound all-trans vitamin A acid dispersible paste and the preparation method and application. The all-trans vitamin A acid dispersible paste comprises all-trans vitamin A acid 10-50 units, beclomeasone propionate 10 -50 units, urea 5000-20000 units and base material 80000-95000 units. The method for preparing paste comprises following steps: (1) collecting 50 -65g urea, 150-180g glycerin, 3-5g dodecyl sodium sulfate, 6-10g triethanolamine, adding water into them unti the weight reaches 400-450g, (2) taking 20 -40g glycerel monostearte, 100-120g geoceric acid, 50 -70g white petrolatum, 190-200g liquid paraffin and 1-3g phenethyl ester as oil phase; (3)putting the two phases into container, heating until dissolution, keeping it at 60-80 Deg. C, pouring oil phase into aqueous phase, adding 0. 125-1g all-trans vitamin A acid, 0. 125-1. 5g beclomeasone propionate, stirring. The paste can be coated on cicatrix directly to prevent cicatrix recurrent, reduce cicatrix coloring matter deposition and promote cicatrix recovery.

Description

technical field [0001] The invention belongs to the field of drugs for treating skin scars, in particular to a compound all-trans retinoic acid cream and its preparation method and application. Background technique [0002] Keloids and hypertrophic scars are fibroproliferative diseases formed by exuberant proliferation of cells at the wound site and excessive secretion of extracellular matrix caused by skin trauma. Keloids are still very prone to recurrence after various treatments such as surgery, laser, freezing, and radiation. After local injection of hormone therapy, the scar can be softened, but the keloid is still prone to relapse after stopping the injection. Although long-term injection of hormone can inhibit its recurrence, the side effects cannot be ignored. Studies have confirmed that the fibroblast differentiation of keloid and hypertrophic scar is abnormal, and the proliferation and apoptosis are unbalanced. This shows that it is possible to promote the differ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/203A61K31/573A61P17/02
Inventor 刘伟武晓莉高振
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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