Synthesis of animal nutrient additive amino-acid-selenomethionine

A technology of selenomethionine and nutritional additives, which is applied in the field of synthesis of selenium-containing amino acid compounds, can solve the problems of harsh reaction conditions, long process route, and high cost, and achieve the effects of mild reaction conditions, good safety, and easy operation

Inactive Publication Date: 2007-11-21
广东新南都饲料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In a word, there are following problems in the existing synthetic method: 1. the preparation of methylselenol negative ion all adopts extremely flammable reagent methyllithium; The reaction conditions are extremely harsh; ③The process route is long, the yield is low, and the cost is high

Method used

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  • Synthesis of animal nutrient additive amino-acid-selenomethionine
  • Synthesis of animal nutrient additive amino-acid-selenomethionine
  • Synthesis of animal nutrient additive amino-acid-selenomethionine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Add 50g CH to a 500ml reaction bottle 3 SeSeCH 3 , add 20ml of DMSO to dilute, add 100ml of 6M NaOH aqueous solution under stirring, keep the temperature at 25°C, add a total of 6g of NaBH in batches 4 , fully stirred and reacted for 5 hours to obtain a transparent solution.

[0036] Add 35g of 4-bromo-α-aminobutyric acid methyl hydrobromide to the above obtained solution, raise the temperature to 60°C, stir and react for 3 hours, after the reaction is completed, add 3M hydrochloric acid to acidify, concentrate to dryness, dissolve with ethanol, Filtrate, collect the filtrate, adjust pH=6-7 with ammonia water, filter, wash, and dry to obtain 14.85 g of metallic luster selenomethionine with a yield of 60%, HPLC content analysis of 98%, and selenium content of 38.5%.

Embodiment 2

[0038] Add 150g CH to a 1000ml reaction bottle 3 SeSeCH 3 , add 100ml DMF for dilution, add 300ml concentration of 8M KOH aqueous solution under stirring, keep the temperature at 60°C, add a total of 64.5g of KBH in batches 4 , fully stirred and reacted for 4 hours to obtain a transparent solution.

[0039] Add 135g of methyl 4-chloro-α-(N-acetyl)aminobutyrate to the solution obtained above, raise the temperature to 40°C, stir and react for 8 hours, after the reaction, add 2M hydrochloric acid to acidify, concentrate to dryness, and wash Dissolve, filter, collect the filtrate, adjust pH=6 to 7 with ammonia water, filter, wash, and dry to obtain 75.2 g of metallic luster selenomethionine with a yield of 55%, HPLC content analysis of 97%, and selenium content of 38.0%.

Embodiment 3

[0041] Add 5 g of CH to a 50 ml reaction vial 3 SeSeCH 3 , add 5ml of HMPA to dilute, add 10ml of 1M NaOH aqueous solution under stirring, keep the temperature at 20°C, add a total of 0.6g of NaBH in batches 4 , fully stirred and reacted for 10 hours to obtain a transparent solution.

[0042] Add 7g of 4-bromo-α-aminobutyric acid hydrobromide to the solution obtained above, raise the temperature to 50°C, and stir the reaction for 5 hours. After the reaction, add 3M hydrochloric acid to acidify, concentrate to dryness, dissolve with ethanol, and filter. The filtrate was collected, adjusted to pH=6-7 with ammonia water, filtered, washed, and dried to obtain 3.18 g of metallic luster selenomethionine with a yield of 61%, an HPLC content analysis of 98%, and a selenium content of 38.5%.

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Abstract

The invention is concerned with a kind of method to produce amino acid-selenium methionine as animal nutrition additive. Take dimethyl diselenide as material and deoxidize it in alkalescence solution to get methyl hydroselenide negative ion with borohydride metal or metal of borohydride. Then react with 4-halogen-alpha-amino acid or its ramification to get selenium methionine through hydrolyzing and adjusting pH valve. The reaction system is carrying in water solution without inert gases and avoids the operation without water and oxygen. The material is common with good safety and it is easy for operation and higher productivity with appropriate condition and it do not need special equipment.

Description

technical field [0001] The invention relates to a synthesis method of a selenium-containing amino acid compound, in particular to a synthesis method of an animal nutrition additive amino acid-selenomethionine. Background technique [0002] Selenium has been proved to be one of the essential nutritional trace elements for animals and human body. Selenium enters the body mainly through the biogeochemical food chain. In animals, selenium is an essential component of glutathione peroxidase and 5'-deiodinase, and is also a component of many proteins in the body. Statistics show that about 2 / 3 of the regions in my country are deficient in selenium. Only by supplementing a certain amount of selenium in livestock and poultry diets can their normal production performance be brought into play. Therefore, supplementing selenium plays an important role in animal production and people's health in my country. meaning. [0003] At present, inorganic sodium selenite (NaSeO) has been used t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/175A23K1/16A23K20/142A23K20/20
Inventor 冉学光林映才周桂莲蒋宗勇
Owner 广东新南都饲料科技有限公司
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