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Novel hydrolysable tannin and application thereof

A technology for hydrolyzing tannins and tannins, which is applied in the field of glucopyranose hydrolyzable tannins, and can solve problems such as not disclosing the use of such compounds

Inactive Publication Date: 2008-02-13
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the above-mentioned article does not disclose the purposes of this type of compound, also does not see other reports

Method used

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  • Novel hydrolysable tannin and application thereof
  • Novel hydrolysable tannin and application thereof
  • Novel hydrolysable tannin and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0041] 1. Obtaining of the compound of the present invention

[0042] (1) Take the wild snake, chop it, soak it with 70% methanol or ethanol at room temperature for 24 hours, filter, and remove the alcohol from the filtrate under reduced pressure to obtain the total extract;

[0043] (2) The total extract is diluted with an appropriate amount of water, then extracted with ether and ethyl acetate successively, and the water-soluble part is taken;

[0044] (3) The water-soluble part is first subjected to MCI-gel CHP20P column chromatography, eluted with water and 10% methanol, and the methanol eluate is collected;

[0045](4) The eluate obtained in step (3) is eluted with Chromatorex ODS with water and then with 10-80% methanol, collects 40-80% methanol eluate, recovers methanol under reduced pressure, and dissolves the residue with a little methanol ; Then apply MCI-gel CHP20P, elute with water and then 10-80% methanol, collect 40-80% methanol eluate, recover methanol under re...

example 2

[0076] 【prescription】

[0077] Hydrolyzable Tannin 10g

[0078] Microcrystalline Cellulose 48g

[0079] Soluble starch 40g

[0080] Talc powder 2g

[0081] A total of 1000 tablets were produced, each containing 100 mg of the compound.

[0082] 【Preparation】

[0083] Weigh 10g of the compound, add soluble starch to dilute to 50g, mix well, then weigh 48g of microcrystalline cellulose, use 95% ethanol to make soft material, sieve and granulate, dry at low temperature at 50°C, granulate, add talc powder 2g , mixed evenly, compressed into tablets (0.1g each), inspected for quality, packaged, and obtained.

[0084] 【Dosage】

[0085] 2-3 tablets each time, 3 times a day.

[0086] 【For people】

[0087] Applicable to various tumor patients.

example 3

[0089] 【prescription】

[0090] Hydrolyzable Tannin 5g

[0091] Microcrystalline Cellulose 48g

[0092] Soluble starch 45g

[0093] Talc powder 2g

[0094] A total of 1000 tablets were produced, each containing 100 mg of the compound.

[0095] 【Preparation】

[0096] Weigh 5g of the compound, add soluble starch to dilute to 50g, mix well, then weigh 48g of microcrystalline cellulose, use 95% ethanol to make soft material, sieve and granulate, dry at low temperature at 50°C, granulate, add talc powder 2g , mixed evenly, compressed into tablets (0.1g each), inspected for quality, packaged, and obtained.

[0097] 【Dosage】

[0098] 2-3 tablets each time, 3 times a day.

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PUM

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Abstract

The invention provides a new caffeoyl-containing glucopyranose hydrolyzable tannin, the chemical structure of which is shown in formula (I). The compound of the invention can inhibit the proliferation of tumors, has good antitumor activity, and can be used to prepare antitumor drugs.

Description

technical field [0001] The invention relates to the field of organic chemistry, in particular to a caffeoyl-containing glucopyranose hydrolyzable tannin. Background technique [0002] Tannins, also known as vegetable tannins, are a class of complex polyphenolic compounds widely present in plants, among which hydrolyzable tannins are esters or glycosides formed of phenolic acids and polyols. [0003] In 2001, Zhi-hong Jiang and Yoko Hirose found a variety of glucopyranose hydrolyzable tannins containing caffeoyl and galloyl groups in snake mushroom (Balanophora japonica Makino), such as: 1-O-(E) -Caffeoyl-3-O-galloyl-β-D-glucopyranose, the compound is a yellow amorphous powder, [α] D 15 -48.9°(c=0.8, MeOH), can be hydrolyzed into gallic acid and 1-O-(E)-caffeoyl-β-D-glucopyranose under the action of tannase; 3-O-(E) -Caffeoyl-4-O-galloyl-D-glucopyranose, the compound is a yellow amorphous powder, [α] D 15 -144.2°(c=0.7, MeOH), under the action of tannase, it can be hydro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H13/08A61K31/7048A61K36/185A61P35/00
Inventor 姜志宏吴少瑜田中山中崇文晓芸刘中秋岩田弘美河野高畑勋吴曙光广濑小野
Owner SOUTHERN MEDICAL UNIVERSITY
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