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Dimeric IAP inhibitors

An alkyl-independent technology for use in the field of IAP dimer inhibitors

Active Publication Date: 2008-02-20
梅迪维尔有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although cytochrome c induces multimerization of Apaf-1 to activate pro-caspase-9 and pro-caspase-3, Smac abolishes inhibition of most IAPs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Wherein R7a and R7b are independently H, alkyl, cycloalkyl, haloalkyl; or R8a and R7a and R8b and R7b can independently or together form a ring, such as aziridine or azetidine ring;

[0130] R8a and R8b are independently H, hydroxyl, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl or heteroaralkyl, wherein alkyl, aryl, aralkyl, Cycloalkyl, cycloalkylalkyl, heteroaryl, and heteroaralkyl are optionally substituted by halogen, hydroxy, mercapto, carboxy, alkyl, alkoxy, amino, and nitro; or R8a And R7a and R8b and R7b can form a ring independently or together, such as aziridine or azetidine ring;

[0131] Wherein R5a and R5b are independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl; or each use the following groups Optionally substituted with: hydroxy, mercapto, halo, amino, carboxyl, alkyl, haloalkyl, alkoxy, or alkylthio; or, in some cases, the R5a and R5b residues are linked via: 2 - alkylene, alke...

Embodiment 2

[0143] Wherein R7a and R7b are independently H, alkyl, cycloalkyl, haloalkyl; or R8a and R7a and R8b and R7b can independently or together form a ring, such as aziridine or azetidine ring;

[0144] R8a and R8b are independently H, hydroxyl, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl or heteroarylalkyl, wherein alkyl, aryl, aralkyl , cycloalkyl, cycloalkylalkyl, heteroaryl, and heteroarylalkyl are optionally substituted by halogen, hydroxy, mercapto, carboxy, alkyl, alkoxy, amino, and nitro; Or R8a and R7a and R8b and R7b can form a ring independently or together, such as aziridine or azetidine ring;

[0145] Wherein R5a and R5b are independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroarylalkyl; or each use the following groups Optionally substituted with: hydroxy, mercapto, halo, amino, carboxy, alkyl, haloalkyl, alkoxy, or alkylthio; or, in some cases, the R5a and R5b residues are linked via: Alkylene, al...

Embodiment 3

[0155] Wherein R7a and R7b are independently H, alkyl, cycloalkyl, haloalkyl; or R8a and R7a and R8b and R7b can independently or together form a ring, such as aziridine or azetidine ring;

[0156] R8a and R8b are independently H, hydroxyl, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl or heteroarylalkyl, wherein alkyl, aryl, aralkyl , cycloalkyl, cycloalkylalkyl, heteroaryl, and heteroarylalkyl are each optionally substituted by halogen, hydroxy, mercapto, carboxy, alkyl, alkoxy, amino, and nitrate or R8a and R7a and R8b and R7b can form a ring independently or together, such as aziridine or azetidine ring;

[0157] R5a and R5b are independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroarylalkyl; or each uses the following groups Optionally substituted with: hydroxy, mercapto, halo, amino, carboxyl, alkyl, haloalkyl, alkoxy, or alkylthio; or, in some cases, the R5a and R5b residues are linked via: 2 - alkylene...

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Abstract

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac / DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inbhibitors, NSAIDs, taxanes and platinum containing compounds use broader language.

Description

[0001] CROSS REFERENCE AND RELATED APPLICATIONS: This application claims priority to the following application, which is hereby incorporated by reference in its entirety into this application: Filed February 25, 2005 entitled "PEPTIDOMIMETICS" U.S. Provisional Application No. 60 / 656,201, filed April 5, 2005, U.S. Provisional Application No. 60 / 668,344, June 2005, entitled "IMMUNOTHERAPeuticuses of SMAC MIMETICS" U.S. Provisional Application No. 60 / 692,111, entitled "PEPTIDOMIMETICS OF SMAC ALONE OR IN COMBINATION WITHTOPOISOMERASE INHIBITORS," filed August 9, 2005, filed on the 20th U.S. Provisional Application No. 60 / 706,649, entitled "PEPTIDOMIMETICS OF SMAC AS CIAP INHIBITORS", entitled "PEPTIDOMIMETICS OF SMAC AS CIAP INHIBITORS" and filed on October 25, 2005, entitled "Alone or in combination with platinum-containing compounds US Provisional Application No. 60 / 729,853 for PEPTIDOMETICS OF SMAC ALONE OR INCOMBINATION WITH PLATINUM CONTAINING COMPOUNDS AND TAXANES". Backgro...

Claims

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Application Information

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IPC IPC(8): C07D209/20A61K31/40A61P35/00
CPCY02A50/30
Inventor S·M·康登M·G·拉波特邓一军S·R·里平
Owner 梅迪维尔有限公司
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