Method of preparing polyvalent vaccine of viable bacteria

A technology of bacilli and coding genes, which is applied in the field of preparation of live multivalent vaccines, can solve the problems of leaving scars, increasing production costs, increasing broiler costs, etc., and achieves the effect of increasing stability

Inactive Publication Date: 2008-02-27
BEIJING GREAT GENIUS SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

Injection of monovalent vaccines will not only cause local inflammatory reactions and leave scars on the skin, but due to the large number of broiler chickens in my country,...

Method used

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Embodiment Construction

[0019] Macrophages play a crucial role in the response of immune responses as antigen-presenting cells. Bacteria that can grow in macrophages, such as Listeria, Mycobacterium tuberculosis, Legionella, Larthenia rabbits, especially Salmonella typhimurium, are widely used as vaccine carriers by inactivating their toxicity and their regulatory genes. Research on various vaccines.

[0020] Except for hepatitis B virus, no other genetically engineered subunit vaccines have been successfully developed yet. The vaccines used in practical work are mainly inactivated or attenuated whole virus vaccines. In these vaccines, almost all viral genes are retained except for mutations or deletions of some genes related to virulence. The current genetically engineered vaccines that use viruses as vectors cannot insert the complete coding sequence of one virus into another virus due to the limited capacity of the virus. In the long-term evolution process, the interaction between the virus and...

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Abstract

The invention discloses a making method of live polyvalent vaccine in the molecular biological domain, which protects five virus infections within one time through sucking and/or intaking expressive infectious bronchitis, marek's disease, facystic disease, newcastle disease and poultry influenza virus.

Description

technical field [0001] The invention belongs to the field of molecular biology, and discloses a preparation method of live bacteria multivalent vaccine, which can express infectious bronchitis, Marek's disease and bursal disease by inhalation and / or oral administration compared with traditional methods , Newcastle disease and avian influenza virus-related antigens attenuated typhimurium, to achieve the purpose of providing protection for the above five kinds of virus infection after one immunization. Background technique [0002] Poultry, especially broiler chicken, is loved by consumers in some western developed countries due to its short production cycle and high nutritional value of chicken. Different from my country's consumption concept, Western consumers especially like to consume whole chickens in addition to eating split chickens. Therefore, there are considerable requirements for the appearance of the whole chicken. At present, most chicken vaccines in my country ...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61P31/12C12N15/31C12N15/33C12N15/63
Inventor 刘吉荣迟云发
Owner BEIJING GREAT GENIUS SCI & TECH DEV
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