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Determining the estimated date of embryo implantation and related dates

A technique for implantation and embryos, which is applied in the field of determining the estimated date of embryo implantation and related dates, and can solve the problems of determining the expected date of delivery, not raising it, etc.

Inactive Publication Date: 2008-03-19
INVERNESS SWITZERLAND GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] To the knowledge of the present inventors, it has not been proposed so far that an expected date of delivery can be determined on the basis of measuring hormones

Method used

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  • Determining the estimated date of embryo implantation and related dates
  • Determining the estimated date of embryo implantation and related dates
  • Determining the estimated date of embryo implantation and related dates

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] As part of a larger study of changes in different hormone concentrations during the female reproductive cycle, samples were collected from a group of female volunteers. The morning urine samples are collected every day and analyzed using standard immunological analysis techniques to obtain the concentration values ​​of various analytes, including hCG, LH, and follicle-stimulating hormone (FSH) in the urine. Subsequent analysis of the data revealed that in those women who became pregnant during the study, as expected, the urine hCG concentration increased rapidly. However, surprisingly, the inventors found that the graph of hormone concentration versus time can be translated along the time axis and overlapped almost completely. That is to say, the process of increasing hCG between different individuals has not changed much, and the difference between different individuals is largely due to the different time when the concentration of hCG starts to rise. The time at which thi...

Embodiment 2

[0049] Based on the data, the inventor was able to derive many algorithms that can be used to estimate the date of implantation based on the measured hCG concentration value. Using the data shown in Figure 1, the following equation can be derived:

[0050] logh=a(t-t 0 ) 0.33 -1.86 (Equation 1)

[0051] Where h is the concentration of hCG in the sample, expressed in mIU / ml, t-t 0 Is the number of days between the date of measurement and the date of implantation, and a is the coefficient (1.99 in this case).

[0052]According to the data obtained using a slightly different hCG analysis technique shown in Figure 2, the value of a was found to be 2.15. The value of parameter a reflects the characteristics of the analysis system used, and generally depends on the specific detection technology used (for example, a specific antibody) and / or the specific form of hCG to be detected. Therefore, the selected system should be calibrated with known standards (for example, samples obtained fro...

Embodiment 3

[0058] In calculating the date of implantation, one cause of uncertainty is that the value of the parameter "a" varies from person to person (although it may be less than the error predicted before the present invention). Another cause of error is that the concentration of hCG in urine fluctuates randomly around the average value in any given day. The present inventors investigated whether the causes of these errors can be reduced by using multiple hCG concentration determinations (for example, two measurements, 7 days apart).

[0059] Estimate the parameters a and t by directly solving Equation 2 using different log(hCG) values ​​obtained on two different days 0 The attempt of was unsuccessful, because cubed the value (log(hCG)-1.86) to magnify the error. The small error in the estimation of a value caused by the small fluctuation of log(hCG) can cause the t 0 Estimated large error. However, the following method seems to work satisfactorily.

[0060] According to Equation 1, the ...

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Abstract

A method of determining the estimated date of implantation of an embryo may include testing a sample of a body fluid from a pregnant human female subject so as to obtain data indicative of the concentration of human chorionic gonadotrophin (hCG) in the sample, and calculating an estimated date of implantation from the hCG concentration data.

Description

[0001] This application claims the rights and benefits of U.S. Provisional Patent Application No. 60 / 563,592 filed on April 20, 2004, and also claims the priority of European Patent Application Ser. No. EP04251289.7 filed on March 5, 2004. Invention field [0002] The present disclosure relates to the determination of the date of implantation of a born embryo for a mammalian subject. The present disclosure also relates to the determination of expected date of delivery (EDD) and possible conception date. Background of the invention [0003] The due date (EDD) is the approximate date of birth that can usually be expected. In practice, for humans, only 5% of births actually occur during the expected delivery date, but about 90% occur within the 10 days before and after the expected delivery date. Because many factors, including clinical and non-clinical factors, depend on the expected date of delivery (for example, scheduling a meeting with an obstetrician, deciding on labor inductio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/76
CPCG01N33/76G01N2333/59
Inventor 戴维·爱德华·威廉姆斯
Owner INVERNESS SWITZERLAND GMBH
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