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Salification method for 2-(6-quinolineamino)-6-cyclopropylamino-9H-purine

A technology of cyclopropylamino and quinolineamino, which is applied in the field of 2--6-cyclopropylamino-9H-purine salt formation, can solve the problems of poor selectivity and large side effects

Inactive Publication Date: 2010-08-11
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, chemical drug therapy mainly has the disadvantages of poor selectivity and large side effects.

Method used

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  • Salification method for 2-(6-quinolineamino)-6-cyclopropylamino-9H-purine
  • Salification method for 2-(6-quinolineamino)-6-cyclopropylamino-9H-purine
  • Salification method for 2-(6-quinolineamino)-6-cyclopropylamino-9H-purine

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Abstract

The present invention discloses process of forming salt with 2-(6-quinolylamino)-6- cyclopropylamino-9H-purine. Compound III is reacted through deprotection reaction and salt forming reaction to prepare compound II. The process of the present invention is simple and suitable for industrial production.

Description

technical field The invention relates to the technical field of medicinal chemistry. Specifically, it relates to a method for forming a salt of 2-(6-quinolineamino)-6-cyclopropylamino-9H-purine (compound I). Compound I Background technique Malignant tumor (cancer) is one of the main diseases that seriously affect human health and threaten human life. No less than 5 million people die from cancer every year in the world. Although some treatment methods such as surgery, radiotherapy, and chemotherapy are available, the cure rate is generally not high. At present, chemotherapy drugs mainly have disadvantages such as poor selectivity and large side effects. Therefore, it has become one of the hot spots to look for anti-tumor drugs with low toxicity, small side effects, high anti-cancer activity and good stability. It is reported that some purine derivatives have certain antiviral and antitumor activities. For details, see relevant reports in pate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D473/16C07D215/00
CPCY02P20/55
Inventor 吴章桂袁建勇陈钢
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY