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Application of 1,3,4-3-O-gallnut acyl-6-O-coffee acyl-beta-D-glucopyranose in preparing antineoplastic medicament
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A kind of technology of glucopyranose and galloyl group, which is applied in the field of medicine and can solve the problems such as no reports on pharmacological activity, application and medicament.
Inactive Publication Date: 2010-07-21
SOUTHERN MEDICAL UNIVERSITY
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No reports on the pharmacological activity, usage and medicament of this compound have been found through literature search
Method used
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[0166] A total of 1000 tablets were produced, each containing 100 mg of the compound.
[0167] 【Preparation】
[0168] Weigh 10g of the compound, add soluble starch to dilute to 50g, mix well, then weigh 48g of microcrystalline cellulose, use 95% ethanol to make soft material, sieve and granulate, dry at low temperature at 50°C, granulate, add talc powder 2g , mixed evenly, compressed into tablets (0.1g each), inspected for quality, packaged, and obtained.
[0179] A total of 1000 tablets were produced, each containing 100 mg of the compound.
[0180] 【Preparation】
[0181] Weigh 5g of the compound, add soluble starch to dilute to 50g, mix well, then weigh 48g of microcrystalline cellulose, use 95% ethanol to make soft material, sieve and granulate, dry at low temperature at 50°C, granulate, add talc powder 2g , mixed evenly, compressed into tablets (0.1g each), quality inspected, packaged, and ready to be obtained.
[0182] 【Dosage】
[0183] 2-3 tablets each time, 3 times a day.
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Abstract
The invention provides an application method of 1, 3, 4-3-tri-O-galloyl acyl -6-O- caffeoyl-Beta-D- glucopyranose in preparing tumor antitumor drugs, in particular the application of glucoseglucopyranose in preparing inducing agent to inhibit the growth of tumor cells and to accelerate tumor cell apoptosis. The invention also provides a tumor antitumor drug, which contains 5 to 20 percent of 1, 3, 4-3-tri-O-galloyl acyl -6-O- caffeoyl-Beta-D- glucopyranose.
Description
technical field [0001] The invention relates to the field of medicine, in particular to the new application of 1,3,4-tri-O-galloyl-6-O-caffeoyl-β-D-glucopyranose. Background technique [0002] 1,3,4-Tri-O-galloyl-6-O-caffeoyl-β-D-glucopyranose is extracted from the aerial parts of Balanophora japonica Makino by methanol A compound isolated from the compound, its chemical formula is as shown in formula I. The compound is a yellow non-crystalline powder that can be hydrolyzed by tannase into gallic acid and 6-O-caffeoyl-β-D-glucopyranose (Caffeoyl, Coumaroyl, Galloyl, and Hexahydroxydiphenoyl Glucoses from Balanophora japonica. Zhi-Hong JIANG, Yoko HIROSE, et. Chem. Pharm. Bull. 49(7) 887-892 (2001) Chem.). There is no report on the pharmacological activity, use and medicament of the compound after searching the literature. [0003] Contents of the invention [0004] The purpose of the present invention is to provide a new application of 1,3,4-tri-O-galloyl-6-O-caffeoy...
Claims
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Application Information
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