Application of giant knotweed rhizome toluylene total glycosides in preparing medicament for treating rheumatic disease

A technology of rheumatic diseases and stilbene, which is applied in the field of research and development of new traditional Chinese medicines, can solve problems such as no preparation method, no application for or obtained invention patent, etc., and achieves strong stability and specificity, easy large-scale production, The effect of simple process

Inactive Publication Date: 2008-06-11
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The production technology of extracting Polygonum cuspidatum extract (the main component is polydatin) and polydatin monomer from Polygonum cuspidatum is relatively mature, and there are many reports in the literature, but there is no preparation method exactly the same as the present invention, and it is used to treat rheumatism There are no reports of diseases, and no reports of applying for or obtaining invention patents

Method used

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  • Application of giant knotweed rhizome toluylene total glycosides in preparing medicament for treating rheumatic disease
  • Application of giant knotweed rhizome toluylene total glycosides in preparing medicament for treating rheumatic disease
  • Application of giant knotweed rhizome toluylene total glycosides in preparing medicament for treating rheumatic disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0172] [Example 1] The preferred preparation method of Polygonum cuspidatum extract

[0173] Get 500 g of Polygonum cuspidatum medicinal material (polygonidin content is 2.55%), pulverize into coarse powder passing through a 10-mesh sieve, percolate with 60% ethanol with 16 times the weight volume of medicinal material at a flow rate of 0.6 L / kg.h, extract the ethanol under reduced pressure , concentrated to an extract with a relative density of 1.05-1.08 (at 60°C), add 6 times the weight of the medicinal material in deionized water to dissolve, centrifuge (3000 rpm, 8 min / time), and use the supernatant at 1L / kg. h flow rate through the D-101 macroporous adsorption resin column (column diameter: column height = 1:10, resin weight is 1.5 times the weight of medicinal materials), with 6 times the volume of D-101 resin deionized water at 1L / kg. h flow rate to remove impurities, then use 10% ethanol that is 6 times the volume of D-101 resin to remove impurities at a flow rate of 1...

Embodiment 2

[0174] [Example 2] The preferred preparation method of Polygonum cuspidatum extract

[0175] Get 220 kg of Polygonum cuspidatum medicinal material (polygonidin content is 2.55%), pulverize into coarse powder passing through a 20 mesh sieve, percolate with 60% ethanol with 14 times the weight and volume of medicinal material at a flow rate of 0.6L / kg.h, extract the ethanol under reduced pressure , concentrated to an extract with a relative density of 1.05-1.08 (at 60°C), add 6 times the weight of the medicinal materials in deionized water to dissolve, centrifuge (3000 rpm, 8 minutes / time), and the supernatant is 0.8L / kg .h flow rate through D-101 macroporous adsorption resin column (column diameter: column height=1:10, resin weight is 1.5 times of medicinal material weight), with 6 times the deionized water of D-101 resin volume with 1L / kg .h flow rate to remove impurities, then use 10% ethanol 6 times the volume of D-101 resin to remove impurities at a flow rate of 0.8L / kg.h, ...

Embodiment 3

[0176] [embodiment 3] the preparation method of preferred dosage form capsule of the present invention

[0177] Take 100 grams of Polygonum cuspidatum extract prepared by the above method, crush it through a 80-mesh sieve, add 40 g of medicinal starch, stir to mix evenly, spray 80% ethanol solution, make soft material, pass through a 40-mesh sieve for granulation, and heat at 60 ° C. Dried, divided into 1000 capsules 3 # In capsules, quality inspection, packaging, ready to go. Each capsule of this product contains polydatin (C 20 h 22 o 8 ), not less than 50mg. [Specification] 140mg / grain; [Function and Indications] Clearing away heat and detoxification, dredging collaterals and relieving pain. It is used for wind, cold, dampness and heat to invade muscles, joints, muscles and bones to block the meridians, resulting in stagnation of qi and blood and blockage of veins. Symptoms include severe pain in the limbs and joints, redness and hotness in the sore spot, swollen eyes...

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Abstract

The invention belongs to the new drugs research and development field of traditional Chinese medicine, which relates to a traditional Chinese medicine compound for curing rheumatic diseases, the main component of the invention is an effective part of polygonum cuspidate stilbene total glycoside which is an effective part of polygonum cuspidate and extracted from polygonum cuspidate which is China's traditional Chinese medicine. The invention first utilizes polygonum cuspidate stilbene total glycoside to cure rheumatic diseases, and treatment effect is better.

Description

[0001] The present invention is a divisional application of the invention patent with the application number 200410091138.3. The original application date is November 19, 2004. The original application name is a traditional Chinese medicine composition for treating rheumatic diseases and its preparation and use. [0002] field of invention [0003] The invention belongs to the field of research and development of new traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating rheumatic diseases. ), and provide the preparation dosage form of the medicine and its preparation method and use. Background technique [0004] Traditional Chinese medicine believes that arthralgia is the muscle meridians blocked by wind-dampness, qi and blood circulation is not smooth, clinically manifested as pain and soreness in the bones, muscles, joints, etc., numbness in severe cases, joint swelling, and poor flexion and extension. It is a co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K31/7034A61K9/20A61K9/48A61P29/00A61K31/047
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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