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Lycopene micropills and preparation thereof

A technology of lycopene and pellets, which is applied in the field of medicine and food, can solve the problems of low bioavailability, irritation of gastric mucosa, and long disintegration time, and achieve high bioavailability, good effectiveness, and reduced total dose Effect

Inactive Publication Date: 2008-07-09
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have disadvantages such as long disintegration time; disintegration at a certain point in the body, which is irritating to the gastric mucosa; and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take the following ingredients for the recipe

[0034] Lycopene

1.5g (based on pure product)

starch

94g

Hydroxypropylmethylcellulose

4.5g

[0035] Prepare pellet formulations as follows:

[0036] (1) Add the lycopene in the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0037] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0038] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0040] Take the following ingredients for the recipe

[0041] Lycopene

5g (based on pure product)

starch

90g

Polyvinylpyrrolidone

5g

[0042] Prepare pellet formulations as follows:

[0043] (1) Add the lycopene in the above-mentioned formula amount to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0044](2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0045] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0047] Take the following ingredients for the recipe

[0048] Lycopene

8g (based on pure product)

Crystalline Cellulose

88.5g

Hydroxypropylmethylcellulose

3.5g

[0049] Prepare pellet formulations as follows:

[0050] (1) Take the lycopene of the above-mentioned formula amount and add the crystal cellulose, pulverize it to a micronization level with a ball mill, and mix well;

[0051] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0052] (3) The pellets are made by the centrifugal-fluidized pelletizing method.

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Abstract

The present invention provides a lycopene pellet preparation which is made from the lycopene and medical auxiliary materials and is characterized in that the medical auxiliary materials are excipient and bond. In the pellet preparation, the weight percentages of the materials are: 1 percent to 10 percent of the lycopene, 70 percent to 95 percent of the excipient and 1 percent to 5 percent of the bond. The pellet preparation of the present invention has high leaching rate and high biological utilization degree, and the preparation method is simple and convenient and is easy for operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of lycopene and a preparation method thereof. Background technique: [0002] Lycopene (Lycopene) is a kind of carotenoid, is a strong antioxidant, has a strong ability to scavenge free radicals, and has a significant effect on the prevention and treatment of prostate cancer, lung cancer, breast cancer, uterine cancer, etc. It also has the effects of preventing cardiovascular and cerebrovascular diseases, improving immunity, and delaying aging. It is known as plant gold and is known as "the new favorite of health care products in the 21st century." It is the strongest antioxidant in nature, its antioxidant effect is 2 times that of β-carotene and 100 times that of VE. Lycopene is more powerful than β-carotene in removing free radicals, the "source of all diseases" in the human body. In 2003, the American "Time" magazine listed lycopene at the top of the ...

Claims

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Application Information

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IPC IPC(8): A61K31/01A61K9/16A61P39/06A61P35/00A23L1/30
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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