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Method for examining pulmonary function and abnormality and composition therefor

A technology for obstructive pulmonary disease and emphysema, applied in the direction of biochemical equipment and methods, microbiological measurement/testing, etc., can solve the problems of unable to significantly change the natural history of COPD, unavoidable exacerbation of shortness of breath, and limited success

Inactive Publication Date: 2008-07-09
SYNERGENZ BIOSCIENCE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Despite advances in the treatment of airway disease, current treatments do not significantly alter the natural history of COPD, leading to progressive loss of lung function, respiratory failure, and death
Although smoking cessation has been shown to slow this decline in lung function, if abstinence is not achieved within the first 20 years of smoking in susceptible smokers, substantial loss of lung function and worsening shortness of breath cannot be avoided
Smoking cessation study shows limited success with technology to help smokers quit

Method used

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  • Method for examining pulmonary function and abnormality and composition therefor
  • Method for examining pulmonary function and abnormality and composition therefor
  • Method for examining pulmonary function and abnormality and composition therefor

Examples

Experimental program
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preparation example Construction

[0462] The present invention also relates to the preparation of kits used in the present invention. Suitable kits include various reagents used in the present invention in suitable containers and packaging materials, including tubes, vials, shrink-wrapped packages, and blow-molded packages.

[0463] Materials suitable for the contents of the exemplary kit of the present invention include one or more of the following materials: gene-specific PCR primer pairs (oligonucleotides) that anneal to the flanking DNA or cDNA sequence of the genetic polymorphism of interest; Reagents that can amplify specific sequence regions in genomic DNA or cDNA without the need for PCR; reagents needed to distinguish the differences between various possible alleles in sequence regions amplified by PCR or non-PCR amplification (E.g. restriction endonucleases, preferably oligonucleotides that anneal to one allele of the polymorphism, including those modified to contain enzymes or fluorescent chemical group...

Embodiment 1

[0475] Example 1: Case correlation study

[0476] Recruitment of objects

[0477] Recruiting subjects of European descent who have been smoking for at least 15 pack years and have been diagnosed with chronic obstructive pulmonary disease (COPD) by a doctor. Subject meets the following criteria: age over 50 years old and symptoms of shortness of breath appear after 40 years old; forced expiratory volume per second (FEV1) is the percentage of predicted value <70% and FEV1 / FVC ratio (forced expiratory volume per second / Forced vital capacity) <79% (measured by the American Thoracic Association standard). 294 subjects were recruited, of which 58% were men, the average FEV1 / FVC (±95% confidence interval) was 51% (49-53), and the average FEV1 as a percentage of the predicted value was 43 (41-45). The average age, number of cigarettes per day and pack-year history were 65 years (64-66), 24 cigarettes / day (22-25) and 50 pack-years (41-55), respectively. It also studied 217 European subjec...

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Abstract

The present invention provides methods for the assessment of risk of developing chronic obstructive pulmonary disease (COPD), emphysema or both COPD and emphysema in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing COPD, emphysema or both COPD and emphysema.

Description

Technical field [0001] The present invention relates to a method for evaluating lung function and / or lung disease, in particular to the use of analysis of genetic polymorphisms and altered gene expression to evaluate the occurrence of chronic obstructive pulmonary disease (COPD) and lungs in smokers and non-smokers Methods of risk of emphysema. The present invention also relates to the use of genetic polymorphism in evaluating the risk of COPD and emphysema in a subject. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in developed countries and the main cause of rehospitalization worldwide. It is characterized by occult inflammation and progressive lung destruction. When more than 50% of lung function has been irreversibly lost, and the affected smoker notices shortness of breath after exercise, COPD becomes clinically significant. This loss of lung function can be clinically detected by a decrease in expiratory flow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor R·P·扬
Owner SYNERGENZ BIOSCIENCE LTD
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