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Application of Chinese traditional medicine compounds on preparing medicines promoting mesenchymal stem cells surviving in the body and cardioblast differentiation

A technology of mesenchymal stem cells and compositions, which is applied in the application field of traditional Chinese medicine compositions in the preparation of drugs that promote the survival of bone marrow mesenchymal stem cells in vivo and the differentiation of myocardium, and can solve problems such as inflammatory response, oxidative stress, and apoptosis. Achieve the effect of improving the local internal environment, improving survival and differentiation ability, and promoting cell cardiomyoplasty

Active Publication Date: 2012-03-21
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Acute myocardial infarction can lead to severe myocardial ischemia, inflammation, oxidative stress and apoptosis, which will significantly reduce the survival rate of transplanted cells

Method used

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  • Application of Chinese traditional medicine compounds on preparing medicines promoting mesenchymal stem cells surviving in the body and cardioblast differentiation
  • Application of Chinese traditional medicine compounds on preparing medicines promoting mesenchymal stem cells surviving in the body and cardioblast differentiation
  • Application of Chinese traditional medicine compounds on preparing medicines promoting mesenchymal stem cells surviving in the body and cardioblast differentiation

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Experimental program
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Effect test

Embodiment 1

[0060] Embodiment 1: the preparation of medicine of the present invention

[0061] a) The raw material drug formula is:

[0062] Ginseng 55g Leech 103.75g Wood Beetle 68.75g Frankincense (made) 22.5g

[0063] Radix Paeoniae Alba 47.5g, Dalbergia 23.75g, Sandalwood 22.5g, Scorpio 68.75g

[0064] 68.75 grams of cicada slough, 13.75 grams of centipede, 13.75 grams of borneol, 46.25 grams of jujube seed (stir-fried);

[0065] b) Crushing process of medicinal materials:

[0066] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 30-40 μm; the medicinal material...

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Abstract

The invention discloses the application of a traditional Chinese medicine combination in the preparation of medicine which enhances the in-vivo survival and cardio blast differentiation of mesenchymal stem cells. The invention also relates to the application of the traditional Chinese medicine compound to the preparation of medicine which cures the cardiovascular disease with autologous mesenchymal stem cells.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to the application of a traditional Chinese medicine composition in the preparation of medicines for promoting bone marrow mesenchymal stem cells' survival and cardiogenic differentiation in vivo. Background technique [0002] Cardiovascular disease kills 12 million people every year, which is close to 1 / 4 of the total death of the world's population, and has become the number one enemy of human health. For myocardial infarction or heart failure, traditional treatment methods, including drugs, intervention and surgery, cannot regenerate the missing cardiomyocytes, and the loss of myocardium causes an irreversible myocardial remodeling process, eventually leading to heart failure and death. In recent years, stem cell regenerative medicine has made breakthroughs in the treatment of cardiovascular diseases. This technology is also known as cellular card...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61K31/045A61K36/71A61K35/62A61P9/10A61P43/00A61K35/646A61K35/648
Inventor 杨跃进钱海燕
Owner HEBEI YILING MEDICINE INST
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