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Medicament for preventing and treating leukopenia used in tumor radiotherapy and chemotherapy course

A technology of leukopenia, radiotherapy and chemotherapy, applied in the direction of antineoplastic drugs, drug combinations, extracellular fluid diseases, etc., can solve the problems of restricted use, preventive drugs not yet proposed, poor curative effect, etc.

Active Publication Date: 2008-08-06
HUBEI MONYAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, CSF has a faster effect on increasing white blood cells, but it can only be used after leukopenia occurs, and cannot be used to prevent
At the same time, CSF has side effects of musculoskeletal pain hypersensitivity and concerns about stimulating tumor cell proliferation, which also limits its use
Some chemical drugs that can improve white blood cell function are rarely used because of their poor efficacy
There are many kinds of traditional Chinese medicines for increasing leukocytes, but their effects are different, and there is a lack of varieties that are generally effective for all patients or most patients, especially the concept of preventive medication has not yet been proposed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Preparation of oral liquid

[0013] Take 80 grams of epimedium, 40 grams of psoralen, 20 grams of aconite (made), 20 grams of medlar, 80 grams of astragalus, 80 grams of spatholobi, 80 grams of madder, 40 grams of angelica, 80 grams of reed root, Ophiopogon japonicus 40 grams, 40 grams of licorice, mix and cook twice. Add 8 times the amount of water each time and boil for 1 hour. Soak for half an hour before the first decoction. After decocting, collect the combined filtrate, put the filtrate into a vacuum concentration pot and concentrate it under reduced pressure (43~47℃, -0.093~0.097Mpa) to a relative density of 1.23~1.27 (25℃); add 95% ethanol to the alcohol content 70%, stand for 72 hours, filter; the filtrate recovers ethanol to no alcohol; the obtained extract is stirred with purified water, boiled for 30 minutes, cooled to room temperature, refrigerated for 48 hours, filtered, and adjusted the pH to 7.0, accurate Replenish purified water to full amount and...

Embodiment 2

[0015] Example 2 Preparation of oral liquid

[0016] Take 60 grams of epimedium, 60 grams of psoralen, 30 grams of aconite (made), 20 grams of medlar, 70 grams of astragalus, 60 grams of spatholobi, 70 grams of madder, 60 grams of angelica, 60 grams of reed root, Ophiopogon japonicus 60 grams and 50 grams of licorice were processed according to the method of Example 1 to produce about 200 ml of oral liquid.

experiment example 1

[0017] Experimental Example 1 Observation of the effect of the drug of the present invention on preventing leukopenia during radiotherapy

[0018] This verification selectively observed 56 patients with advanced cancer who were given 40ml of "Shengbai Oral Liquid" prepared according to the method in Example 1 or 2 during radiotherapy, 3 times a day, as the experimental group; and the patients in the same period were classified according to gender, age, Type of disease, disease period, irradiation method, irradiation dose and irradiation area, non-randomly select a pair as the control group. The control group was given scyllohydrin 100mg during radiotherapy, 3 times a day, orally, Lixuesheng 20mg, daily 3 times, orally. Among them, there were 89 males and 23 females; the youngest was 38 years old, the oldest was 73 years old, and the average age was 57 years; 62 cases of esophageal squamous cell carcinoma, 26 cases of lung squamous cell carcinoma, 10 cases of lung adenocarcinoma, a...

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PUM

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Abstract

The invention discloses a medicine used for preventing and treating leucopenia in the process of tumor radiotherapy and chemotherapy. The effective raw material and the weight proportion thereof is as follows: 6-8 shares of barrenwort, 3-6 shares of fructus Psoralea, 1-3 shares of aconite root (prepared), 1-3 shares of medlar, 6-8 shares of radix astragali, 6-8 shares of milettia reticulate, 6-8 shares of madder, 3-6 shares of angelica, 6-8 shares of reed rhizome, 3-6 shares of liriope spicata and 3-6 shares of liquorice. The optimal formulation of the medicine is oral liquid.

Description

Technical field [0001] The invention relates to a medicine made with traditional Chinese medicine botanicals as raw materials, and also relates to a preparation method of the medicine. Background technique [0002] Radiotherapy and chemotherapy are two of the most commonly used and most important methods for the treatment of malignant tumors. Radiation therapy and chemotherapy have a common side effect-bone marrow suppression. The bone marrow hematopoietic function is suppressed, the patient develops anemia, and the immune function further declines. Among them, the white blood cell decline is the most obvious. Leukopenia makes patients very susceptible to serious infections, sometimes in those who are life-threatening due to infections. Leukopenia often leads to the interruption of planned radiotherapy and chemotherapy regimens, which leads to tumor cell proliferation, spread, and metastasis. [0003] In China alone, about 1.8 to 2 million malignant tumor patients require radioth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P7/00A61P35/00
Inventor 邵振启
Owner HUBEI MONYAN PHARMA CO LTD
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