Medicament for preventing and treating leukopenia used in tumor radiotherapy and chemotherapy course

A technique for leukopenia, radiotherapy and chemotherapy, applied in anti-tumor drugs, drug combinations, extracellular fluid diseases, etc., can solve the problems of poor curative effect, stimulation of tumor cell proliferation, and lack of commonly effective varieties for patients.

Active Publication Date: 2011-04-06
HUBEI MONYAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, CSF has a faster effect on increasing white blood cells, but it can only be used after leukopenia occurs, and cannot be used to prevent
At the same time, CSF has side effects of musculoskeletal pain hypersensitivity and concerns about stimulating tumor cell proliferation, which also limits its use
Some chemical drugs that can improve white blood cell function are rarely used because of their poor efficacy
There are many kinds of traditional Chinese medicines for increasing leukocytes, but their effects are different, and there is a lack of varieties that are generally effective for all patients or most patients, especially the concept of preventive medication has not yet been proposed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 Preparation of oral liquid

[0013] Take 80 grams of epimedium, 40 grams of psoralen, 20 grams of aconite (made), 20 grams of medlar, 80 grams of astragalus, 80 grams of Caulis Spatholobus, 80 grams of madder, 40 grams of angelica, 80 grams of reed root, and Radix Ophiopogon japonicus. 40 grams, 40 grams of licorice, mix together and decoct twice. Add 8 times the amount of water each time and boil for 1 hour. Soak for half an hour before the first decoction. After decocting, collect the combined filtrate, put the filtrate into a vacuum concentrating pot under reduced pressure (43~47°C, -0.093~0.097Mpa) and concentrate to a relative density of 1.23~1.27 (25°C); add 95% ethanol to the alcohol content 70%, stand still for 72 hours, filter; recover ethanol from the filtrate until it has no alcohol smell; add an appropriate amount of purified water to the obtained extract, stir for 30 minutes, cool to room temperature, refrigerate for 48 hours, filter, adjust ...

Embodiment 2

[0015] Embodiment 2 Preparation of oral liquid

[0016] Take 60 grams of epimedium, 60 grams of psoralen, 30 grams of aconite (made), 20 grams of medlar, 70 grams of astragalus, 60 grams of Caulis Spatholobus, 70 grams of madder, 60 grams of angelica, 60 grams of reed root, Radix Ophiopogon japonicus 60 grams, 50 grams of Radix Glycyrrhizae, processed by the method of embodiment 1 and made about 200ml oral liquid.

experiment example 1

[0017] Experimental example 1 Observation of the effect of the medicine of the present invention on preventing leukopenia in the radiotherapy process

[0018] This verification selectively observes 56 cases of middle and advanced cancer patients who are given 40ml of "Shengbai Oral Liquid" prepared according to the method of Example 1 or 2 during radiotherapy, 3 times a day, as the experimental group; Disease type, disease stage, irradiation mode, irradiation dose and irradiation area, non-random selection paired as the control group, the control group was given batyl alcohol 100mg, 3 times a day, orally during radiotherapy, and lexogen 20mg, daily 3 times, orally. Among them, there were 89 males and 23 females; the youngest was 38 years old, the oldest was 73 years old, and the average age was 57 years old; there were 62 cases of esophageal squamous cell carcinoma, 26 cases of lung squamous cell carcinoma, 10 cases of lung adenocarcinoma, and 4 cases of poorly differentiated ...

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PUM

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Abstract

The invention discloses a medicine used for preventing and treating leucopenia in the process of tumor radiotherapy and chemotherapy. The effective raw material and the weight proportion thereof is as follows: 6-8 shares of barrenwort, 3-6 shares of fructus Psoralea, 1-3 shares of aconite root (prepared), 1-3 shares of medlar, 6-8 shares of radix astragali, 6-8 shares of milettia reticulate, 6-8 shares of madder, 3-6 shares of angelica, 6-8 shares of reed rhizome, 3-6 shares of liriope spicata and 3-6 shares of liquorice. The optimal formulation of the medicine is oral liquid.

Description

technical field [0001] The invention relates to a medicine made from traditional Chinese medicinal plant medicine, and also relates to a preparation method of the medicine. Background technique [0002] Radiation therapy and chemotherapy are two of the most commonly used and most important means of contemporary treatment of malignant tumors. Radiation therapy and chemotherapy have a common side effect -- bone marrow suppression. The hematopoietic function of the bone marrow is inhibited, the patient develops anemia, and the immune function further declines, among which the decrease of white blood cells is the most obvious. Leukopenia makes patients prone to serious infections, sometimes life-threatening infections. Leukopenia also often leads to the interruption of planned radiotherapy and chemotherapy regimens, resulting in tumor cell proliferation, spread, and metastasis. [0003] In China alone, about 1.8 to 2 million malignant tumor patients need chemotherapy and radi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P7/00A61P35/00
Inventor 邵振启
Owner HUBEI MONYAN PHARMA CO LTD
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