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Biological adhesive agent and use thereof

A bioadhesive and biomacromolecule technology, applied in the field of medical and bioengineering supplies, can solve the problems of patients infected with blood viruses, stimulating immune side reactions, and low bonding strength

Active Publication Date: 2012-02-29
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, fibrin glue made from allogeneic human or animal serum may stimulate immune side effects, and there is a danger of infecting patients with blood viruses, so the safety of its clinical use has attracted widespread attention.
At the same time, fibrin glue is not combined with the tissue by chemical bonds, and the bonding strength is low.

Method used

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  • Biological adhesive agent and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Preparation of the present bioadhesive

[0016] Weigh 0.5 g of azidobenzoylated polylysine powder with a molar percentage of azidobenzoylation structural unit of 25%, place it in a small beaker, add 19.5 g of distilled water, stir and dissolve to obtain azidobenzoyl The bioadhesive with a weight percent concentration of acyl polylysine of 2.5% is sucked into the prepared bioadhesive with a 10ml injection needle and set aside.

Embodiment 2

[0018] Adhesion between active physiological tissues

[0019] New Zealand white rabbits were used as experimental animals. There were 3 New Zealand white rabbits, all male, weighing 2000g±150g. The experiment is divided into an experimental group and a control group, with the New Zealand white rabbit back spine as the boundary, the left side is the control group, the right side is the experimental group, the control group uses a blank control, and the experimental group uses the bioadhesive of the present invention. Rabbits were anesthetized by intravenous injection of 2% pentobarbital sodium aqueous solution at a dose of 30 mg / Kg body weight, and the rabbits were fixed on the operating frame with their backs facing up, and the back hair was shaved off with a razor blade , and use Promogeramine cotton balls for skin disinfection. Taking the central skin of the back spine as the boundary, use a sterilized scalpel blade to take a piece of skin with a length of 3 cm, a width of ...

Embodiment 3

[0022] Packing and trapping of physiological pipeline

[0023] Cut a section of the small intestine of the rat, 8 cm long, discharge the contents of the small intestine, ligate one end, insert the injection needle into the other end and then ligate, so that the injection needle and the syringe are connected; use another injection needle to pierce a small hole on the intestinal wall, and Place the ligated small intestine with a small hole in a beaker filled with water, push air into the ligated small intestine with a syringe, so that the intestinal tube is naturally filled, and the small intestine leaks air. Take the small intestine out of the water, drop a drop of this bioadhesive on the punctured part, irradiate with ultraviolet light for 2 minutes, and solidify, then put the small intestine into a beaker filled with water, and slowly push air into the intestinal tube with a syringe , no gas leaks from the small intestine. The test results show that the bioadhesive of the pr...

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Abstract

The invention discloses a biological adhesive which is characterized in that the adhesive comprises two parts which are solute and solvent; the solute is an azide benzoylate acidylated biomacromolecule compound; the solvent can be water, water for injection, normal saline, washing liquor of Ringer solution, washing liquor of mannitol, washing liquor of dextrose, washing liquor of chlorhexidine, washing liquor of gentamicin normal saline, washing liquor of glycin, washing liquor of metronidazole or physiologic balance solution; the weight percentage concentration of the azide benzoylate acidylated biomacromolecule compound in the biological adhesive is 0.1 percent to 20 percent. When in use, the biological adhesive needs to be solidified by using ultraviolet irradiation. The biological adhesive of the invention can be used for bonding active physiological tissues, wadding and patching physiological channels, sealing surface of wound to stanch bleeding, bonding physiological materials with non-physiological materials as well as bonding non-physiological materials, with short clotting time.

Description

technical field [0001] The invention relates to a medical and bioengineering product, in particular to a bioadhesive and its application. Background technique [0002] Medical adhesives have many uses in the medical field and bioengineering field, including closed repair of active physiological tissue wounds of humans and animals, closed hemostasis of surgical wounds, adhesion between active physiological tissues, and bonding between active physiological tissues and non-physiological materials. Adhesion, as well as the adhesion of tissue and cells in tissue engineering. Medical adhesives can be divided into chemical adhesives and biological adhesives according to their material properties. Chemical adhesives such as α-cyanoacrylates have been used clinically for many years, but tissue toxicity caused by their degradation products is unavoidable. Bioadhesives such as fibrin glue are a kind of medical wound sealant. They are protein biological products extracted from human o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61K47/36A61K31/795A61L24/04A61L24/10A61K47/34A61P7/04A61K47/42A61K31/785
Inventor 韩宝芹刘万顺陈列欢彭燕飞杨艳董文
Owner OCEAN UNIV OF CHINA
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