Operation irrigating solution and preparation method thereof

A surgical irrigation solution and irrigation solution technology, applied in the field of medicine, can solve problems such as poor stability, single function, toxic and side effects, and achieve the effects of good stability, promotion of injury healing, and no toxic and side effects

Inactive Publication Date: 2015-11-11
NANJING TZONE BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many surgical irrigation solutions used in domestic and foreign surgical operations, but there are very few products that can prevent postoperative tissue adhesion and promote wound healing
And the existing disclosed washing solution still has certain defects, for example, there are many defects such as certain toxic and side effects, poor stability, single function, etc.

Method used

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  • Operation irrigating solution and preparation method thereof
  • Operation irrigating solution and preparation method thereof
  • Operation irrigating solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Preparation of 0.03% (mass fraction, the same below) hyaluronic acid surgical flushing solution (A): Measure 1000ml of normal saline in a beaker, add 0.3g of hyaluronic acid, stir to dissolve, and use a 0.22 micron filter to obtain the concentration It is 0.03% hyaluronic acid surgical irrigation solution (A).

Embodiment 2

[0016] Preparation of 0.05% Hyaluronic Acid Surgical Fluid (B): Measure 1000ml of 5% glucose solution in a beaker, add 0.5g hyaluronic acid, stir to dissolve, and use a 0.22 micron filter to obtain a concentration of 0.05% hyaluronic acid Acid Surgical Fluid (B).

Embodiment 3

[0018] Preparation of 0.1% Hyaluronic Acid Surgical Fluid (C): Measure 1000ml of water for injection into a beaker, add 8.5g, 0.16g of sodium dihydrogen phosphate, and 0.04g of disodium hydrogen phosphate in turn, stir to dissolve, and then add 1g of transparent Hyaluronic acid, after dissolving, use a 0.22 micron filter to obtain a concentration of 0.1% hyaluronic acid surgical flushing solution (C).

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Abstract

The invention relates to the field of medicines, and particularly relates to an operation irrigating solution and a preparation method thereof. The irrigating solution comprises sodium hyaluronate and a solvent. The irrigating solution is characterized in that the solvent is normal saline, injection water, a ringer solution irrigating solution, a glucose irrigating solution, a mannitol irrigating solution, a chlorhexidine irrigating solution, a gentamycin normal saline irrigating solution, a povidone iodine irrigating solution, a bromogeramine irrigating solution, a glycine irrigating solution, a metronidazole irrigating solution or a physiological balanced solution; and the concentration of the sodium hyaluronate in the operation irrigating solution is 0.1-10g/L. The operation irrigating solution has the effects of operation irrigation, has functions of preventing adhesion and promoting wound healing after operation, and has the advantages of no toxic or side effect, good stability and excellent effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an operation washing liquid and a preparation method thereof. Background technique [0002] Our country has a large population, and a large number of patients undergo surgical operations every day. During the surgical operation, the tissues of the organs are exposed to the air due to the operation, resulting in dryness and oxidation of the tissues, resulting in tissue adhesion after the operation and prolonging the wound healing time. According to statistics, more than 90% of surgical operations will involve the problem of postoperative tissue adhesion. Tissue adhesion is regarded as a common pathological reaction in the medical field. It is the connection between connective tissue fibers and adjacent tissues due to tissue trauma during surgery. Or an abnormal structure formed by the joining of organs. Postoperative tissue adhesions occur in abdominal and pelvic surgery, orthopedic surge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/722A61K33/14A61K33/18A61P41/00A61K31/7004A61K31/7036A61K31/14A61K31/198A61K31/4164A61K31/155
Inventor 金玉徐林
Owner NANJING TZONE BIOLOGICAL SCI & TECH
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