Application of compound and composition thereof in preparation of medicines for improving lung repair activity

A technology of pharmaceuticals and compositions, applied in the field of compounds and their compositions used to prepare pharmaceuticals that enhance lung repairing activity, to achieve the effects of enhancing lung repairing activity, promoting growth and wound repairing ability

Pending Publication Date: 2021-07-16
百岳特生物科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are currently limited drugs that are known to effectively enhance lung repair activity, and these drugs may not be able to enhance lung repair activity

Method used

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  • Application of compound and composition thereof in preparation of medicines for improving lung repair activity
  • Application of compound and composition thereof in preparation of medicines for improving lung repair activity
  • Application of compound and composition thereof in preparation of medicines for improving lung repair activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1. Purification of compounds TCI-PN-01 and TCI-PN-02

[0028] The compound purified in this example is obtained from green pear fruitlet, and its species can be Sydney (P.nivalis), Yali (P.bretschneideri), bird pear (P.lindleyi Rehder), or Hengli Sorbet (P.pyrifolia Nakai), but not limited thereto, among which Sydney, Yali, or bird pear are preferred.

[0029] As used herein, the term "green pear fruitlet (green pear fruitlet)" means the green pear fruit of Sydney, Yali, bird pear, or Hengshan pear within 90 days after flowering, preferably within 30 to 90 days green pear fruit.

[0030] Pear is the general term for plants of the genus Pyrus. It is usually a deciduous tree or shrub. The leaves are mostly ovate, and the size varies with different varieties. The flowers are white, or yellowish or pink, with five petals. The shape of the fruit is round, and there are also those with a thin base and a thick tail, which is commonly known as "pear shape". Brow...

Embodiment 2

[0040] Example 2. Efficacy Evaluation of Compounds TCI-PN-01 and TCI-PN-02 in Improving Lung Repair Activity

[0041] In this example, human normal lung epithelial cell line BEAS-2b (ATCC CRL-9609) purchased from American Type Culture Collection (ATCC) was used. The cells were cultured in bronchial epithelial basal medium (Lonza TM Bronchial epithelial cell basal medium; Thermo Fisher Scientific), referred to as BEBM medium.

[0042] In order to study whether the compounds TCI-PN-01 and TCI-PN-02 affect the wound repair ability of lung tissue, this example uses a microscope to observe the cell monolayer of the human lung epithelial cell line BEAS-2b through the compound TCI-PN-01 or TCI - Changes in wound healing status after PN-02 treatment. Briefly, cells were divided into 1.5 × 10 5 Cells / well were seeded in 24-well plates (GeneDireX) containing BEBM medium and incubated overnight at 37°C to form a cell monolayer. Thereafter, a wound was formed in the cell monolayer, t...

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Abstract

The invention relates to a novel application of a compound, in particular to an application of a compound and a composition thereof in preparation of medicines for improving lung repair activity. The invention provides an application of the composition for improving lung repair activity. The composition is selected from a group consisting of chlorogenic acid, beta-androstane, any combination of the chlorogenic acid and the beta-androstane, and a pharmaceutically acceptable carrier. The invention also provides an application of the chlorogenic acid or the beta-androstane in preparation of the medicines for improving lung repair activity.

Description

technical field [0001] The present invention relates to a new use of a compound, in particular to the use of a compound and its composition for preparing medicines for improving lung repairing activity. Background technique [0002] The lungs are both breathing organs and filtering organs. The lungs usually secrete mucus to form a protective layer to prevent pathogens (such as viruses, bacteria, fungi) or aerosols in the inhaled air from adsorbing to the lungs. However, the ability of the lung to remove foreign matter is limited, and some foreign matter may penetrate this protective layer and infect or damage the lungs, causing lung inflammation. In addition, pulmonary contusion, sepsis, hemorrhagic shock, etc. can cause severe lung inflammation. A variety of immune cells (such as macrophages, neutrophils) involved in the inflammatory response and the stimulated secretion of pro-inflammatory cytokines (such as interleukin, tumor necrosis factor-α (TNF-α)) may cause lung re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K31/216A61P11/00
CPCA61K31/7034A61K31/216A61P11/00A61K2300/00
Inventor 林咏翔
Owner 百岳特生物科技(上海)有限公司
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