Dextran

Abstract

The invention relates to a glucose, in particular to an anti-lung cancer glucose. The main chain of the glucose of the invention is constituted of the following repeating structural units with the molecular weight of 1.5 million to 2.5 million Dalton. The glucose of the invention is mainly used for preparing anti-lung cancer drugs.

Description

technical field [0001] The invention relates to a glucose polymer, in particular to a glucan for anti-lung cancer. Background technique [0002] Lung cancer, a malignant tumor, has become the number one killer that threatens human health. The incidence of lung cancer has increased at a rate of 11.90% in the past 10 years with the aggravation of environmental pollution. In 2000, there were more than 10 million new cases of malignant tumors in the world, and 6.2 million deaths, including 1.239 million new cases of lung cancer, accounting for 12.32% of the total cancer cases, and 1.103 million deaths from lung cancer, accounting for 17.77% of the total deaths. top. At present, 1.5-1.8 million people die of lung cancer every year in the world, and the hazard situation of lung cancer in my country is even more serious, calculated according to the incidence rate of 83.43 per 100,000 people. There are no less than 1 million new lung cancer patients in my country every year, and a...

AI Technical Summary

Problems solved by technology

But once clinically diagnosed as lung cancer, 80% of patients have just lost the chance of surgical resection; and radiation therapy has local limitations and damage to normal tissues; chemical (drug) therapy has universal cytotoxicity and its Dose limitation; especially severe toxic and side effects on liver, kidney, bone marrow and digestive system, greatly restricting the therapeutic effect of lung cancer

Emerging interventional therapy has a certain effect on the primary tumor, but it is difficult to deal with the constantly sporadic metastases; modern molecular targeted (gene) therapy has brought hope to lung cancer patients, but its vector construction, cross-linking of vector and warhead and Many issues such as its distribution in the body and changes in the metabolic process are still under discussion.

[0004] The inventors have previously studied that slug PE-40 glycoprotein has a direct inhibitory effect on small cell lung cancer and non-small cell lung cancer cells and a synergistic effect on chemotherapy drugs such as DDP and 5-FU and cytokine TNF-a, Moreover, there are no obvious toxic and side effects; the overall effect is better than other traditional Chinese medicines, but due to the protein content, there are problems of sensitization and stability that are difficult to control, which limits the scope of application to a certain extent

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