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Ultrasonic responsive bone repair material, production method and use thereof

A manufacturing method and bone repair technology, applied in the field of biomedical engineering, can solve problems such as limited light penetration depth

Inactive Publication Date: 2016-06-29
SHENZHEN RES INST THE CHINESE UNIV OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limited penetration depth of light in tissues, PDT, PDI and PACT have great limitations in clinical application

Method used

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  • Ultrasonic responsive bone repair material, production method and use thereof
  • Ultrasonic responsive bone repair material, production method and use thereof
  • Ultrasonic responsive bone repair material, production method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Observation of the killing effect of the sound-sensitizer on Staphylococcus aureus under the action of ultrasonic waves on bacteria cultured in vitro: culture target bacteria: select Staphylococcus aureus, and routinely cultivate it in an incubator containing 5% carbon dioxide and saturated water vapor at 37°C middle; then, the target bacteria in the logarithmic growth phase (1×10 6 cfu / ml), adding a sonosensitizer such as chlorine6 and incubating for 15 minutes at 37°C in an incubator containing 5% carbon dioxide and saturated water vapor, because some sonosensitizer chloride6 may not be phagocytized by the target bacteria, and is still free in the In the culture solution, so before the ultrasonic action, wash several times to remove the residual chloride6 in the culture solution; then, apply ultrasonic (frequency is 1.0MHz, sound intensity is 1.56W / cm 2 ) to irradiate the target bacteria. Under the action of ultrasonic waves, the sonosensitizer chlorine6 u...

Embodiment 2

[0031] Example 2: Pour the sonic sensitizer hypocrellin into absolute ethanol, mix well, then filter and exhaust to make a hypocrellin solution; then, put bone repair materials in the hypocrenin solution Take it out after dipping for 10 seconds to 4 hours; dry it with nitrogen; repeat the above steps 1-3 times, and finally dry it with nitrogen to obtain an ultrasound-responsive bone repair material.

[0032] In this embodiment 2, the selected sound sensitizer is a safe and non-toxic sound sensitizer that can generate active oxygen species under the action of ultrasonic waves. In addition to hypocretin, it can also be aluminum phthalocyanine, 5- Aminolevulinic acid, monoasparagine chlorin, dexamethorphyrin lutetium, rose bengal, hematoporphyrin, hematoporphyrin monomethyl ether, and the like.

Embodiment 3

[0033] Example 3: Add the sound sensitizer rose bengal (rosebengal) into polyaminoacid (polyamineacid) and stir thoroughly, then, apply the resulting liquid on the surface of the bone repair material; dry it naturally or blow it dry with nitrogen to obtain an ultrasonic response material for bone repair.

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Abstract

The present invention relates to an anti-infection ultrasonic responsive bone repair material, a production method thereof and use of a sound-sensitive material in production of the anti-infection ultrasonic responsive bone repair material to prevent infection. The ultrasonic responsive bone repair material is a bone repair material containing the sound-sensitive material, the surface of the bone repair material is covered with the sound-sensitive material, or the sound-sensitive material is added in the process of the production of the bone repair material, so that the sound-sensitive material is contained in the bone repair material, under the effect of ultrasonic wave, the sound-sensitive material on the surface of the bone repair material or in the bone repair material is activated into reactive oxygen species to kill microorganisms and prevent bone infection, the ultrasonic responsive bone repair material can be applied to all clinical bone defect repairs to prevent infection after implantation of the bone repair material, and the effect of bone repair materials in the prior art cannot match the effect of the ultrasonic responsive bone repair material.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering. More specifically, the invention relates to an ultrasonic-responsive bone repair material with anti-infection function, a manufacturing method and an application thereof. Background technique [0002] Bone defect is one of the common diseases in clinical orthopedics. As the world population continues to grow and age, bone defects caused by trauma, infection, and tumor resection are increasing. In the United States, as many as one million surgical procedures require bone repair materials each year. This drives the vigorous development of bone repair materials. [0003] Currently, bone repair materials in clinical application mainly include polymethyl methacrylate, alumina ceramics, bioglass, tricalcium phosphate, titanium metal, bone cement, and biomaterials based on hydroxyapatite / calcium sulfate. Chinese patent (CN102390941) discloses a medical α-calcium sulfate hemihydrate art...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/28A61L27/10A61L27/12A61L27/50A61L27/54A61K41/00A61P31/02
Inventor 许川山梁荣能
Owner SHENZHEN RES INST THE CHINESE UNIV OF HONG KONG
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