Chinese medicinal composition for treating ischemic stroke and preparation thereof

A composition and drug technology, applied in the field of pharmaceutical composition and its preparation, can solve the problems of poor controllability of preparation quality, complex extract components, and differences in drug efficacy, so as to control cerebral ischemic symptoms and rapidly reduce cerebral ischemic symptoms , to avoid the effect of the first-pass effect

Inactive Publication Date: 2008-11-12
CHONGQING MEDICAL UNIVERSITY
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  • Summary
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  • Description
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AI Technical Summary

Problems solved by technology

The commonality of the technical solutions involved in these patent applications is that the components of the extract are complex, and it is impossible to prove which components in th

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0015] Preparation process Dissolve 2.512g of pyroside and 1.212g of geniposide in 980ml of water for injection, stir to dissolve, add 0.1% activated carbon of the solution volume, stir and adsorb for 30min, when the temperature drops below 40°C, add Stir to dissolve the prescribed amount of sodium chloride and chlorobutanol, adjust the pH to 5.0-7.0 with 0.1mol L hydrochloric acid, remove carbon, add water for injection to the full amount of 1000ml, and use 0.22μm micro Fine filter with porous membrane, filled with nitrogen, potted, sterilized by circulating steam at 100°C for 30 minutes, inspected by light, packaged, ready to be obtained.

Embodiment approach 2

[0017] Take 1.816 g of qualified pyroside and 2.182 g of geniposide according to the weight of the formula, and dissolve them with an amount of water for injection about 50% of the total amount of water for injection in the formula. Activated carbon for needles is added in an amount of 0.05% to 0.15% of the total amount. Stir evenly and let stand for 8-12 hours, filter to remove activated carbon, add water for injection to about 90% of the total amount, and add disodium edetate and sodium bisulfite in the prescribed amount. Use 15% sodium hydroxide or 15% hydrochloric acid solution to adjust the pH value to 5.0-7.0, and add water for injection to a total of 1000 ml of formula water. Then first filter with a 0.65μm filter membrane, then fine filter with a 0.45μm filter membrane, and then fill and seal.

Embodiment approach 3

[0019] Take 94g of pyroside and 62g of geniposide according to the weight of the formula, add starch and dilute to 260g, mix well, wet granulate with 75% ethanol, pass through a 60-mesh sieve after drying, add 0.8% magnesium stearate, mix well , divided into capsules to make 1000 capsules, and the finished product is obtained after passing the inspection.

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PUM

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Abstract

The invention relates to a drug composition a method for preparing the same, in particular to a drug composition for curing cerebrovascular disorder caused cerebral ischemia and a method for preparing the same. The drug composition is prepared by combining effectively two monomeric compounds of nicotiflorin and gardenoside according to optimal proportion of prescription. According to the experiment of regional cerebral ischemia and reperfusion in rat, the drug composition has a strong protective effect on cerebral ischemia and reperfusion injury and has effectiveness more remarkable than that of monomeric compound used alone.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating cerebral apoplexy caused by cerebral ischemia and a preparation method thereof. technical background [0002] Ischemic stroke is a common and frequently-occurring disease that seriously endangers human health. It has the characteristics of high morbidity, disability and mortality. It has leapt to the top of various causes of death in many countries and regions. So far, there is no drug that can achieve the desired effect on the treatment of acute stroke. Traditional Chinese medicine plays a unique role in the prevention and treatment of ischemic cerebrovascular disease, which is also the characteristic and advantage of our country. However, the traditional Chinese medicine injections currently on the market, such as safflower injection, Chuanxiong injection, Naoxuekang injection, Erigeron breviscapus inject...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10A61K36/286A61K36/744
Inventor 于超何俊琳
Owner CHONGQING MEDICAL UNIVERSITY
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