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Medicine for increasing intra-abdominal pressure

A technology of intraperitoneal pressure and drugs, applied in the direction of drug combination, etc., can solve the problems of reducing intraperitoneal pressure without hydroxyethyl starch and hydroxyethyl starch, and achieve the effect of reducing the effect, good medicinal prospects, and strong pharmacological effects

Active Publication Date: 2011-10-12
BEIJING FRESENIUS KABI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] There is no report that hydroxyethyl starch is used to prepare drugs for the prevention and treatment of intra-abdominal pressure
At present, there are no studies and reports on the use of hydroxyethyl starch for reducing intra-abdominal pressure

Method used

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  • Medicine for increasing intra-abdominal pressure
  • Medicine for increasing intra-abdominal pressure
  • Medicine for increasing intra-abdominal pressure

Examples

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Embodiment 1

[0044] This embodiment takes severe acute pancreatitis (SAP) as the research object, and the reason for selecting SAP patients as the implementation object is that the intra-abdominal pressure increase caused by SAP is more typical, and the pathophysiological process of its intra-abdominal pressure increase is different from other The pathophysiology of disease-induced elevated intra-abdominal pressure is similar.

[0045] Severe acute pancreatitis (SAP) can occur in the early stage of systemic inflammatory response syndrome (SIRS), leading to multiple organ dysfunction (MODS), and in severe cases, multiple organ failure (MOF). The prognosis of SAP is dire, and the literature reports a case fatality rate of 20-30%. If MODS is complicated, the case fatality rate is as high as 50%.

[0046] One of the early characteristic symptoms of SAP is high abdominal distension and significantly increased intra-abdominal pressure. In 2005, Waele et al. found that the incidence of increased...

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Abstract

The invention provides a new application of a middle molecular weight hydroxyethyl starch in reducing intra-abdominal pressure. The middle molecular weight hydroxyethyl starch has molecular weight of 60,000-600,000 Da, molar degree of substitution of 0.15-0.5, and C2 / C6 hydroxyethyl substitution ratio of 5-20. The inventive hydroxyethyl starch can effective reduce the intra-abdominal pressure; and can be used for preventing and treating increase of the intra-abdominal pressure caused by inflammatory reactions.

Description

technical field [0001] The invention relates to a medicine for treating elevated intra-abdominal pressure. Background technique [0002] The abdominal cavity is relatively isolated from the outside world, so anything that increases the volume of the abdominal contents can increase intra-abdominal pressure. Many reasons can cause an acute increase in intra-abdominal pressure (IAP), and abdominal compartment syndrome (abdominal compartment syndrome, ACS) is the outcome of an acute increase in intra-abdominal pressure. Increased volume of abdominal contents is the most common cause of increased intra-abdominal pressure, including intra-abdominal hemorrhage, edema, intestinal obstruction, mesenteric vein obstruction, abdominal tamponade, massive ascites, peritonitis, liver transplantation, and tumors; CO during laparoscopy 2 Pneumoperitoneum can also adversely affect heart, lung, and kidney function External compression of the abdomen can also lead to increased intra-abdominal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/718A61P43/00
Inventor 王春友吴国平王凯姜洪池张肇达区金锐
Owner BEIJING FRESENIUS KABI PHARM CO LTD