Thrombus target contrast agent of magnetic nuclear resonance and preparation method thereof

Abstract

The invention discloses a nuclear magnetic resonance thrombus target-directed contrast agent and a preparation method thereof. The agent is large molecule polymer that is coupled by PsL-EGFmAb and Gd-DTPA-serum albumin. One molecule monoclonal antibody in the contrast agent can have 70 to 100 Gd<3+>. The target-directed contrast agent of the invention can gather at a local part of the thrombus specifically, target-directed development can be realized, the thrombus signal value is earlier than the reinforcing development of normal contrast agents and has obvious reinforcing effect, and the contrast agent can be used for early diagnosis of thrombus formation.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance targeting contrast agent, in particular to a monoclonal antibody-based nuclear magnetic resonance thrombus targeting contrast agent and a preparation method thereof. Background technique [0002] Thrombotic disease is a blood return disorder disease that seriously endangers human life and health, including arterial thrombosis and venous thrombotic disease, involving various clinical subjects such as cardiology, cerebrovascular thromboembolism, deep vein thrombosis, and pulmonary embolism. Complications and peripheral arterial occlusive disease, and the morbidity, mortality and disability rates are high. [0003] At present, the clinical imaging diagnosis of thrombotic diseases mainly relies on angiography, Doppler ultrasound, radionuclide angiography and other techniques. However, the above-mentioned techniques have disadvantages such as the need to inject contrast agents, radionuclides, or a high ...

AI Technical Summary

Problems solved by technology

However, the above-mentioned techniques have disadvantages such as the need to inject contrast agents, radionuclides, or high false positive rates, and when the thrombus is diagnosed, patients generally have clinical symptoms or irreversible organic changes

Magnetic resonance imaging (MRI) is a completely non-invasive imaging diagnostic method, but common contrast agents such as paramagnetic contrast agent gadolinium diethylenetriaminepentaacetate (Gd-DTPA) are used to detect thrombus in MRI. ), etc., cannot specifically enhance early thrombus

Therefore, the early diagnosis of thrombus is limited, so that it is difficult to grasp the optimal thrombolytic treatment time, which in turn affects its therapeutic effect. In short, there is still a lack of specific early diagnosis methods for thrombus.

Images