Niclosamide controlled release dispersing agent for killing blood fluke cercaria and preparation method thereof

A technology for killing schistosome cercariae and niclosamide, which is applied in the field of new niclosamide controlled-release diffusion formulations, can solve the problems of difficulty in ensuring uniform release and free diffusion of active ingredients, dependence on drug efficacy release, and difficulty in achieving control effects, and the like, To achieve the effect of preventing infection, good effect, scientific and reasonable ratio
CN101366376AInactive Publication Date: 2009-02-18扬州绿源生物化工有限公司 +3
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
扬州绿源生物化工有限公司
Publication Date
2009-02-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a niclosamide controlled-release dispersing agent for killing schistosoma japonicum cercaria and a preparation method thereof. The niclosamide controlled-release dispersing agent for killing the schistosoma japonicum cercaria is characterized in that the compositions of the niclosamide controlled-release dispersing agent are niclosamide, paradichlorobenzene, floating carriers and a dispersing agent and the main compositions of the niclosamide controlled-release dispersing agent are the niclosamide and the paradichlorobenzene, wherein the weight ratio of the niclosamide to the paradichlorobenzene is between 10 and 30 to between 90 and 70. The niclosamide controlled-release dispersing agent and the preparation method have scientific and reasonable formula and ratio, advanced and simple technique and good effect of killing the schistosoma japonicum cercaria. The controlled-release dispersing agent for killing the schistosoma japonicum cercaria, which is prepared by processing the niclosamide, the paradichlorobenzene, corncob particles and so on as materials, is applied to a pathogen generation water area, releases the niclosamide at a fixed quantity in virtue of sublimation of the paradichlorobenzene, freely diffuses in virtue of the molecular tension and the function of the dispersing agent, reaches the predicted concentration in a water body, has long lasting period, effectively kills the schistosoma japonicum cercaria, and prevents the schistosoma japonicum cercaria from infecting human beings and livestock; and the death rate of the schistosoma japonicum cercaria reaches 100 percent.
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Description

technical field

[0001] The invention relates to a new dosage form of controlled-release diffusion of niclosamide for killing cercariae of schistosomiasis, in particular to a new dosage form of niclosamide, which uses niclosamide as the original drug, p-dichlorobenzene as the melting agent and corn cob as the floating carrier, with quantitative release, A controlled-release diffusion agent for killing schistosomiasis cercariae with the functions of free diffusion, stable floating and sustained effect and a preparation method thereof. Background technique

[0002] Schistosomiasis japonicum is a zoonotic disease parasitized by Schistosoma japonicum as the pathogen, humans and animals are the final hosts, and snails are the only intermediate hosts of Schistosoma japonicum. The life cycle of schistosomiasis includes six stages: adult, egg, miracidium, sporidia, cercariae and juvenile worm. From the miracidium to the snail to the formation of the cercariae, the asexual reproducti...

Claims

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