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Method for solid-state fermentation processing process for traditional Chinese medicine

A technology of solid-state fermentation and traditional Chinese medicine, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of long production cycle and unsuitable for industrialization, improve the proportion and potency, and promote the beauty of Latin America German reaction, the effect of broadening the source of strains

Inactive Publication Date: 2009-04-08
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this technology only ferments a single drug or a simple combination of drugs
In this fermentation method, traditional Chinese medicine is only used as mycelium fermentation bacteria, and it is still a single strain fermentation method of fungal medicine itself. This fermentation method has a very long production cycle and is not suitable for industrialization requirements.

Method used

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  • Method for solid-state fermentation processing process for traditional Chinese medicine
  • Method for solid-state fermentation processing process for traditional Chinese medicine
  • Method for solid-state fermentation processing process for traditional Chinese medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Gradient acclimatization of the fermented strain Penicillium insolens. The initial concentration of acclimatization is 80%, the acclimatization gradient is 2.5%, and the acclimatization is repeated 5 times. Observe the acclimation result, select the mixture of 85% (g / g) traditional Chinese medicine compound and bran as the acclimatization medium through acclimatization for many times;

[0028] Chinese medicine compound and bran are evenly mixed at 80% (g / g), then the water content of the culture medium is adjusted to 100% with distilled water, the culture medium is sterilized for 30 minutes, and cooled for later use;

[0029] The mixture of the determined 85% (g / g) Chinese medicine compound and bran is used as the medium for the solid-state fermentation of the Chinese medicine compound, the medium is sterilized, cooled, inoculated with Penicillium specificum, and placed in an incubator for 7 days at 28°C;

[0030] The solid-state fermentation product of the traditional...

Embodiment 2

[0032] Gradient domestication of the fermented strain Rhizopus oryzae. The initial concentration of acclimatization is 60%, the acclimatization gradient is 2.5%, and the acclimatization is repeated 5 times. Observe the acclimation result, select the mixture of 62.5% (g / g) traditional Chinese medicine compound and bran as the acclimatization medium after acclimatization for many times;

[0033] Chinese medicine compound and bran are evenly mixed at 60% (g / g), then the water content of the culture medium is adjusted to 150% with distilled water, the culture medium is sterilized for 30 minutes, and cooled for later use;

[0034] The mixture of the determined 62.5% (g / g) Chinese medicine compound and bran is used as the medium for the solid-state fermentation of the Chinese medicine compound, the medium is sterilized, cooled, inoculated with Rhizopus oryzae, and placed in an incubator at 30° C. for 5 days;

[0035] After the solid-state fermentation products of traditional Chines...

Embodiment 3

[0037] Gradient domestication of the fermented strain Aspergillus oryzae. The initial concentration of domestication is 80%, the gradient of domestication is 2.5%, and the domestication is repeated 7 times. Observe domestication result, select the mixture of 90% (g / g) Chinese medicine compound and bran as domestication medium through domestication for many times;

[0038] The traditional Chinese medicine compound and wheat straw are evenly mixed at 80% (g / g), then the water content of the medium is adjusted to 150% with distilled water, the medium is sterilized for 30 minutes, and it is cooled for later use;

[0039] The mixture of the determined 90% (g / g) Chinese medicine compound and wheat straw is used as the medium for the solid-state fermentation of the Chinese medicine compound, the medium is sterilized, cooled, inoculated with Aspergillus oryzae, and placed in an incubator at 30° C. for 5 days;

[0040]The solid-state fermentation product of the traditional Chinese med...

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Abstract

The invention discloses a method for the solid state fermentation processing treatment of a Chinese traditional medicine, which is characterized in that the method comprises the steps of the screening and acclimation of Chinese medicine fermentation medical microbes, the preparation of Chinese medicine solid state fermentation culture medium and the solid state fermentation processing of the Chinese medicine. In the method, the solid state fermentation of the microbes is used as a method for processing the Chinese medicine, thereby breaking the limitation that the prior solid state fermentation Chinese medicine processing is mainly the self fermentation of fungus Chinese medicine and widening the source of the fungus species for the Chinese medicine solid state fermentation processing. Moreover, the method fully utilizes the microbe conversion and biological catalytic action, improves chemical compositions and the efficacy of the Chinese medicine compound and promoting the Maillard reaction of the Chinese medicine compound.

Description

technical field [0001] The invention belongs to the research field of a key technology platform for the modernization of traditional Chinese medicine. In particular, it relates to a method using microbial solid-state fermentation as a means of processing traditional Chinese medicines. Background technique [0002] Fermentation is one of the methods of processing traditional Chinese medicines. For example, Jianshenqu, Agarwood, Douchi, Banxiaqu, Hongqu, malt, etc. are all medicines formed through fermentation; It is fermented by silkworm infected by Beauveria bassiana. These classic drugs have produced new pharmacological activities after microbial fermentation. However, these varieties are all fermented by using natural strains in nature, which belong to unconscious natural fermentation. At the same time, the range of microbial species introduced is greatly limited. It is difficult for those microorganisms that are not dominant in nature and have harsh growth conditions gr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00C12N1/14C12N1/20
Inventor 陈洪章邱卫华张思婧王华敬
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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