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Process for producing vitamin B6

A vitamin and reaction technology, applied in metabolic diseases, organic chemistry, drug combination, etc., can solve the problems of reactant destruction, reduction of reaction yield, color fluctuation of finished products, etc., to reduce the degree of damage, improve product quality, and improve the quality of finished products Effect

Active Publication Date: 2009-04-08
江西天新药业股份有限公司
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  • Application Information

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Problems solved by technology

[0004] Traditional B vitamins 6 In the process, the temperature required for the Diels-Alder reaction (Diels-Alder reaction) is as high as 150°C, and the existence of traces of water and other impurities in the system can lead to the destruction of the reactants, thereby reducing the reaction yield of this step
The use of industrial hydrochloric acid in production, the introduction of Fe 3+ and other metal ions, it is easy to cause quality fluctuations such as the color of the finished product

Method used

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Embodiment Construction

[0014] The present invention will be further described below with specific embodiment:

[0015] Vitamin B 6 The preparation method is basically the same as the conventional method, and its difference is included in the following steps:

[0016] Step 1, preparation of Diels-Alder adduct:

[0017] Add 841g of 2-n-propyl-4,7-dihydro-1,3-dioxepin into the reaction flask and heat up to 150°C, then add 75g of 4-methyl-5-alkoxy-oxazole and 0.1g of triethylamine, heat preservation within the temperature range of 140°C to 160°C for 10 to 20 hours, and then carry out reduced pressure distillation under the condition of vacuum degree of 15mmHg, reduce the distillation until there is basically no distillate, and then obtain Diels- Alder adduct, certainly, above-mentioned triethylamine basic reagent also can be replaced with alkylamine reagents such as trimethylamine, diethylamine, dipropylamine, tripropylamine;

[0018] Step 2, prepare vitamin B with Diels-Alder adduct 6 :

[0019] A...

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Abstract

The invention belongs to the technical field of vitamin production, and relates to a method for preparing vitamin B6. The method comprises Diels-Alder reaction, aromatization reaction, hydrolysis reaction and refining steps, and is characterized in that 2-n-propyl-4, 7-dihydro-1, 3-dioxepin and 4-methyl-5-alkoxyl-oxazole are added with alkali reagent in the process of the Diels-Alder reaction, and are added with a metal ion complexing agent in the process of the aromatization reaction. The invention has the advantages that the method for preparing the vitamin B6 allows damage degree of reactant and product of raw material to be reduced in the process of the Diels-Alder reaction, and improves the performance of the Diels-Alder reaction. Addition of the metal ion complexing agent in the aromatization reaction removes metal ions in a system, thereby improving product quality.

Description

technical field [0001] The invention belongs to the technical field of vitamin production and relates to vitamin B 6 method of preparation. Background technique [0002] Vitamin B 6 It is a substance necessary for humans and animals to maintain normal physiological functions. It participates in the metabolism of amino acids and proteins in the body, maintains the balance of sodium and potassium in the body, regulates body fluids, resists dermatitis and hair loss, and participates in the production of red blood cells. Therefore, vitamin B 6 Used as a therapeutic human and animal vitamin B 6 Auxiliary treatment of deficiency or other diseases, it is also often used as food and feed additive. [0003] Currently, vitamin B 6 The production of oxazole is widely prepared by the oxazole method. In the oxazole method, the basic steps are: Diels-Alder reaction, aromatization reaction, hydrolysis reaction and refining steps. [0004] Traditional B vitamins 6 Due to the temperat...

Claims

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Application Information

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IPC IPC(8): C07D213/67A61P3/02
Inventor 郭军魏欣章根宝
Owner 江西天新药业股份有限公司
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