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Collagenase for treating cellulite

A cellulite, fat technology, used in pharmaceutical formulations, preparations for skin care, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2009-04-08
THE RES FOUND OF STATE UNIV OF NEW YORK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Until today there is still no effective treatment for cellulite

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] method

[0034] Ten patients, all female, mean age 41 = 10 years participated in the study programme. The average body mass index (BMI) was 28.

[0035] The minimum area of ​​cellulite that needs to be included on the posterolateral thigh of the above patient is 10 x 10 cm. All patients had areas of cellulite on their posterolateral thighs that exceeded a minimum 10 x 10 cm area. Baseline digital photographs were taken of the treated areas. 10000 ABC units (0.58 mg) were injected aseptically into the 10 x 10 cm target cellulite area through five points. The total fluid volume for the above injections was 1.0 mL. The buffer used was sterile 0.9% NaCl and 2 mM CaCl. All patients were flowed on the first day, first week, first month, third month and sixth month after receiving the injection. Continuous photographs were taken of them after treatment.

[0036] To achieve cosmetic symmetry, when patients reach the 4-6 week interval after their first collagenase injec...

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PUM

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Abstract

The invention relates to the discovery that collagenase injections are effective in dissolving and lysing the collagenous septa network in the skin which comprises cellulite. As such, the invention relates to methods of treating cellulite in a patient in need of such treatment comprising injecting or otherwise delivering the effective amount of purified collagenase to the collagenous septa network of cellulite in the skin. The invention also relates to the use of collagenase in the manufacture of a medicament to treat cetlulite of the skin.

Description

[0001] priority [0002] This application claims priority to application Serial No. 60 / 775,690, which was filed on February 22, 2006 with the US Patent and Trademark Office. [0003] governmental support [0004] This invention was supported in part by grant M01RR10710 from the National Institutes of Health. The US Government has certain rights in this invention. Background technique [0005] Dimpling of the skin or the "mattress phenomenon" of the thighs and buttocks is often referred to as cellulite. This symptom is common and occurs in different healthy individuals, and it afflicts women more frequently than men. A number of over-the-counter topical treatments currently exist to eliminate cellulite. These products, as well as other over-the-counter topical treatments, have proven ineffective, costly, and have virtually never been subjected to placebo-controlled clinical studies. A recent randomized placebo-controlled trial of topical retinol and retinol containing caff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K8/66
CPCA61K8/66A61Q19/06A61K2800/91A61K38/4886
Inventor M·A·巴达勒门特A·B·达盖姆
Owner THE RES FOUND OF STATE UNIV OF NEW YORK