Compound scutellaria microemulsion formulation and preparation method thereof

A technology of compound scutellaria baicalensis and emulsion preparation, which is applied in the directions of pharmaceutical formulation, emulsion delivery, and medical preparations of inactive ingredients, etc., can solve the problems of low bioavailability of oral preparations, affecting the curative effect of the prescription, poor water solubility of baicalin, etc. The effect of convenient storage and administration, easy absorption, and simple preparation method

Inactive Publication Date: 2009-04-15
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor water solubility of baicalin, the main active ingredient of Scutellaria baicalensis in the prescription, the bioavailability of oral preparations is low
Due to the

Method used

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  • Compound scutellaria microemulsion formulation and preparation method thereof
  • Compound scutellaria microemulsion formulation and preparation method thereof
  • Compound scutellaria microemulsion formulation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 1.17 g of Scutellaria baicalensis extract, add 2 g of caprylic acid triglyceride, 13.3 g of polyoxyethylene hydrogenated castor oil, 6.67 g of 1,2-propanediol, stir evenly (40°C), add the corresponding extracts of honeysuckle and forsythia , continue to add dropwise water to an appropriate amount, adjust the pH value to 7.0 with sodium hydroxide, add water to 100ml, and stir well. Refrigerate for 24 hours. Filter and add water to full volume. Fill, sterilize, and get ready.

[0027] The preparation of Scutellaria baicalensis extract:

[0028] Scutellaria baicalensis pieces were boiled three times with water. Combine the decoction, filter, add hydrochloric acid solution to adjust pH value to 1~2 after filtrate concentration, keep warm for 1 hour, let stand, filter, add water to precipitate and mix, adjust pH value to 7.0 with 40% sodium hydroxide, then add etc. amount of ethanol, stirring to dissolve and filter. The filtrate was adjusted to pH 2 with hydrochlo...

Embodiment 2

[0032] Weigh 2 g of caprylic acid triglyceride, 13.3 g of polyoxyethylene hydrogenated castor oil, 6.67 g of 1,2-propanediol and the extracted volatile oil, stir evenly (40°C), add Scutellaria baicalensis, Forsythia suspensa, and honeysuckle extract, continue Add water dropwise to an appropriate amount, adjust the pH to 7.0 with sodium hydroxide, add water to the full amount, and stir well. Refrigerate for 24 hours. Filter and add water to 100ml. Fill, sterilize, and get ready. The preparation of Scutellaria baicalensis, Forsythia suspensa, honeysuckle extract and volatile oil:

[0033] Weigh 30 g of Scutellaria baicalensis, 60 g of Forsythia suspensa, and 30 g of honeysuckle and boil for 3 times, and collect the volatile oil at the same time for the first time. Combine the decoction and concentrate. Ethanol was added to make the alcohol content reach 60%, left standing, filtered, and ethanol was recovered from the supernatant until there was no alcohol smell. spare.

Embodiment 3

[0035] Weigh 1.17 g of Scutellaria baicalensis extract, add 2 g of soybean oil, 15.0 g of polysorbate 80, and 9.67 g of glycerol, stir well, add the corresponding extracts of honeysuckle and forsythia, continue to add water to an appropriate amount, add 30 g of sugar, and stir to make Dissolve the sugar, adjust the pH to 7.0 with sodium hydroxide, add water to the full amount, and stir well. Refrigerate for 24 hours. Filter and add water to 100ml. Fill, sterilize, and get ready.

[0036] Wherein, the preparation methods of Scutellaria baicalensis extract and Lonicerae Forsythia extract are the same as those in Example 1.

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Abstract

The invention provides a compound scutellaria microemulsion preparation, which is a microemulsion solution prepared by adding emulsifying agent, auxiliary emulsifying agent, oil phase and water into the extractive of scutellaria, forsythia and honeysuckle. The preparation method comprises the following steps: under proper temperature, mixing the emulsifying agent, the auxiliary emulsifying agent and the oil phase evenly, adding the extractive of the scutellaria, the forsythia and the honeysuckle, adjusting pH, slowly dropping distilled water to the mixture under the condition of stirring, and finally obtaining the preparation. The compound scutellaria microemulsion prepared by the preparation method is a red brown clear solution, and the average particle diameter of the microemulsion is 25 to 32 millimicrons; and the preparation method is simple, and the microemulsion is easy to absorb, convenient to store and take, and has good stability and higher bioavailability of effective component of baicalin.

Description

technical field [0001] The invention relates to a microemulsion preparation of a compound traditional Chinese medicine and a preparation method thereof, in particular to a microemulsion preparation containing Scutellaria baicalensis, Forsythia and honeysuckle and a preparation method thereof. Background technique [0002] Microemulsion is a transparent or translucent, low viscosity, isotropic and thermodynamically stable oil-water mixing system spontaneously formed by oil phase, water phase, emulsifier and co-emulsifier in appropriate proportions. The particle size of the microemulsion is uniform, generally between 10-100 nm. Previous studies have shown that microemulsion, as a new type of drug carrier, has the characteristics of low viscosity, stability and rapid absorption, which can promote the absorption of macromolecular drugs in the body, improve the bioavailability of drugs, reduce toxic and side effects, and have clinical application prospects. widely. The applicat...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/107A61K47/10A61K47/14A61K47/34A61K47/44A61P11/00A61P31/00
Inventor 杨华易红卢炜张关敏
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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