Preparation method of doxycycline long-acting injection
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A technology of doxycycline and injection, which is applied in the field of preparation of veterinary drugs, can solve the problems of short half-life, achieve long half-life, reduce stress response, and save manpower and time
Inactive Publication Date: 2009-04-29
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Problems solved by technology
Mainly solve the technical problem of the short half-life of the existing common doxycycline injection
Method used
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preparation example Construction
[0036] The preparation method of doxycycline long-acting injection of the present invention, its injection formula is as follows:
[0037] Doxycycline 5-20g
[0038] Propylene glycol 10g--60g
[0039] MgCl 2 2-4g
[0040] Na 2 S 2 o 5 0.2-0.5g
[0041] Add water for injection to 100ml
Embodiment 1
[0043] Take doxycycline 10g, propylene glycol 20g, PEG-400 30g, MgCL 2 2g, Na 2 S 2 o 5 0.2g, add water for injection to 100ml, the preparation method is:
[0044] ①Mix propylene glycol and PEG-400 first, then add doxycycline to the mixed solvent to obtain solution (1);
[0045] ② Take another MgCL 2 、Na 2 S 2 o5 be dissolved in water for injection to obtain a solution (2);
[0046] ③ Slowly add the solution (2) to the solution (1), stir as it is added, and adjust the pH value to 7.5;
[0047] ④Finally, add water for injection to 100ml, filter, pot, and sterilize at 100°C for 30 minutes.
Embodiment 2
[0049] Take doxycycline 10g, doxycycline hydrochloride 10.8g, propylene glycol 40g, MgCl 2 2g, Na 2 S 2 o 5 0.2g, add water for injection to 100ml, the preparation method is:
[0050] ① first add doxycycline to propylene glycol to obtain solution (1);
[0051] ②Take another doxycycline hydrochloride, MgCL 2 、Na 2 S 2 o 5 be dissolved in water for injection to obtain a solution (2);
[0052] ③ Slowly add the solution (2) to the solution (1), stir as it is added, and adjust the pH value to 8.0;
[0053] ④Finally, add water for injection to 100ml, filter, pot, and sterilize at 100°C for 30 minutes.
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Abstract
The invention discloses a doxycycline long-acting injection which has the formula as follows: 5g to 20g of doxycycline, 10g to 60g of propylene glycol, 2g to 4g of MgCl2, 0.2g to 0.5g of Na2S2O5, and water used for injection. The preparation method comprises the following steps: 1. the doxycycline is added into the propylene glycol to obtain a solution (1); 2. the doxycycline hydrochloride, the MgCl2 and the Na2S2O5 are taken and dissolved in the water used for injection to obtain a solution (2); 3. the solution (2) is slowly added into the solution (1) and stirred while being added, and ethylene diamine is used for regulating the pH value to be 7.5 to 8.5; and 4. the water used for injection is added till the total volume reaches 100ml, and filtering, encapsulation and flowing steam sterilization at the temperature of 100 DEG C for 30min are carried out to obtain the finished product. The doxycycline long-acting injection has the advantages of less dosage, long half-life period, less adverse reaction, and the like.
Description
Technical field: [0001] The invention relates to a preparation method of veterinary medicine, in particular to a preparation method of doxycycline long-acting injection. Background technique: [0002] Doxycycline is a broad-spectrum antibacterial drug, which has strong antibacterial effect on most Gram-positive and Gram-negative bacteria. Protozoa etc. are also very sensitive. Doxycycline is the deoxygenated substance of oxytetracycline, and it is a powerful tetracycline antibiotic. Its antibacterial principle is to block the various links of bacterial protein synthesis, inhibit the replication of bacteria, and achieve antibacterial effects. Doxycycline hydrochloride preparations have been used to treat swine panting for a long time, and the clinical response is good. And existing bibliographical reports, doxycycline hydrochloride for injection treatment acute and chronic bacterial, mycoplasma infection of respiratory system and urinary system is definite curative effect, ...
Claims
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