Saponin compound extracted from Momordica grosvenori root, preparation and use thereof

A technology of saponins and compounds, which is applied in the field of preparation of saponins and the above-mentioned saponins, and can solve problems such as no reports of water-soluble saponins
CN101440118AInactive Publication Date: 2009-05-27GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
Publication Date
2009-05-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the medicine technical field, in particular to saponin compounds of Siraitic acid IIB and Siraitic acid IIC which are extracted and separated from fructus momordicae roots, a method for preparing the same and application thereof in an anti-tumor medicine. The molecular formulas of the two compounds are C40H60O14 and C41H62O15 respectively. By various modern spectral analysis, particularly the application of advanced two-dimensional nuclear magnetic resonance spectrum to comprehensive analysis, the chemical structures of the two compounds are determined. In vitro anti-tumor tests show that the compound Siraitic acid IIB can obviously inhibit lung cancer cells A-549 and liver cancer cells Hep-G2, and the compound Siraitic acid IIC can also obviously inhibit liver cancer cells Hep-G2. The invention provides lead compound for research on a new anti-tumor medicine, and has essential values in comprehensively developing and utilizing fructus momordicae resources.
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Description

(1) Technical field:

[0001] The invention relates to the technical field of medicine, in particular to a saponin compound with a novel structure isolated from the root of Luo Han Guo; the invention also relates to a preparation method and application of the saponin compound. (two) background technology:

[0002] Luo Han Guo Siraitia grosvenrii (Swingle) C. Jeffrey is a perennial rhizome plant of Cucurbitaceae Luo Han Guo. It is a unique economic and medicinal plant in my country and a traditional specialty in northern Guangxi. Luo Han Guo has a well-developed root system, hypertrophic root tubers, bitter taste, and slightly cold nature. It has the effects of clearing away heat and dampness, dredging collaterals and relieving pain. Pharmacological experiments have shown that the extract of Luo Han Guo root has various effects such as anti-inflammatory, analgesic, decomposing stems, and reducing enzymes. Clinical trials have proved that it has a significant effect on rheumatoi...

Claims

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