Polyacrylamide/calcium phosphate nano-composite material and microwave auxiliary liquid phase preparation method thereof

A nanocomposite material, polyacrylamide technology, applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the constraints on the performance and application of composite materials, the agglomeration of calcium phosphate nanoparticles, and the inhomogeneity of the two phases of composite materials Dispersed and combined to achieve the effects of biotoxicity, environmental friendliness, broad application prospects, and controllable morphology and phase

Inactive Publication Date: 2009-07-29
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, some preparation methods separate the polymerization of organic monomers and the formation of inorganic calcium phosphate nanoparticles, so that the two phases of the composite material cannot be uniformly dispersed and combined, and the agglomeration of calcium phosphate nanoparticles is serious. These drawbacks restrict properties and applications of composite materials

Method used

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  • Polyacrylamide/calcium phosphate nano-composite material and microwave auxiliary liquid phase preparation method thereof
  • Polyacrylamide/calcium phosphate nano-composite material and microwave auxiliary liquid phase preparation method thereof
  • Polyacrylamide/calcium phosphate nano-composite material and microwave auxiliary liquid phase preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 0.458g CaCl 2 2H 2 O, 0.025g (NH 4 ) 2 S 2 o 8 and 2.708g of acrylamide monomer were dissolved in 40mL of deionized water, and 10mL of 0.192mol / L (NH 4 ) 2 HPO 4 Aqueous solution, adjust the pH value to 10 with ammonia water during the dropwise addition. After the dropwise addition, the milky white suspension was transferred to a 100 mL flask, placed in a microwave reactor, heated to 80° C. and kept for 45 minutes. The colloidal liquid obtained by the reaction is cooled and added dropwise to absolute ethanol to produce a white precipitate, centrifuged, washed with absolute ethanol, and dried at 60°C to obtain a polyacrylamide / hydroxyapatite nanocomposite material.

Embodiment 2

[0027] 0.087g Ca(CH 3 COO) 2 ·H 2 O, 2.679g acrylamide monomer and 0.028g (NH 4 ) 2 S 2 o 8 Dissolve in 12.5mL deionized water, add 37.5mL buffer solution (containing 0.090gNa 2 HPO 4 12H 2 O and 0.041 g NaH 2 PO 4 2H 2 0, pH=5), mix well to form a stable solution. The solution was transferred to a 100 mL flask, placed in a microwave reactor and heated to 80 °C for 60 minutes. The colloidal liquid obtained by the reaction is cooled and added dropwise to absolute ethanol to produce a white precipitate, centrifuged, washed with absolute ethanol, and dried at 60°C to obtain a polyacrylamide / amorphous calcium phosphate nanocomposite material.

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Abstract

The invention relates to a preparation method for microwave-assisted liquid phase of polyacrylamide / calcium phosphate nano composite material. The preparation method takes water-soluble calcium salt, phosphate and acrylamide as raw materials, takes water as solvent, and obtains the nano composite material of the polyacrylamide and the calcium phosphate of different phases by controlling Ph valve. The two phases in the polyacrylamide / calcium phosphate nano composite material are evenly scattered and the thermal stability is increased. The preparation method has the advantages of simple technique, fast, controllable appearance and phase, low cost, low biotoxicity, environment friendly, etc.

Description

technical field [0001] The invention relates to a polyacrylamide / calcium phosphate nanocomposite material and a microwave-assisted liquid phase preparation method thereof, belonging to the field of nanocomposite material preparation. Background technique [0002] Polymer / calcium phosphate nanocomposites are an important class of biomaterials, which combine the excellent properties of organic polymers and inorganic calcium phosphates, and can effectively improve their biological properties. Polymer / calcium phosphate nanocomposites have important application value and broad application prospects in the fields of tissue engineering, early diagnosis of diseases, drug / gene carrier and so on. In recent years, some methods for preparing polymer / calcium phosphate composites have been developed, such as physical blending, in-situ polymerization, in-situ generation, co-precipitation, and electrochemical deposition. However, some preparation methods separate the polymerization of orga...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/26C08K3/32C08F2/44C08F120/56A61K47/32
Inventor 朱英杰汤启立王可伟陈峰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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