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Application of vincetoxicoside B in preparing antidiabetic medicament

An anti-diabetic and albinoside technology, applied in drug combinations, metabolic diseases, pharmaceutical formulations, etc., to broaden the selection field and achieve significant anti-diabetic effects

Active Publication Date: 2009-08-12
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report that astragaloside B has hypoglycemic activity

Method used

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  • Application of vincetoxicoside B in preparing antidiabetic medicament
  • Application of vincetoxicoside B in preparing antidiabetic medicament
  • Application of vincetoxicoside B in preparing antidiabetic medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Effects of albinoside B on experimental type 2 diabetic rats

[0018] 1 animal group

[0019] Healthy Wistar rats (SPF grade), male, weighing 180-220g (provided by the Experimental Animal Center of Southern Medical University), were given free access to water and food, and were randomly divided into a normal control group and a model group, and the model group was established as follows, After the successful modeling, the animals in the model group were randomly divided into the model control group, the positive drug gliclazide group, and the albinoside B high, middle and low groups, and the administration was continued for 1 week according to the table below.

[0020] The administration time and dosage are shown in Table 1:

[0021] Table 1 Grouping of animals in the efficacy experiment of astragaloside B

[0022]

[0023] 2 Rat model preparation

[0024] The rats in the normal group were fed with distilled water every day, and the rats in the high-fat group were...

Embodiment 2

[0035] Protective effect of astragaloside B on islet β-cell apoptosis induced by streptozotocin

[0036] 1 Experimental method

[0037] Streptozotocin is a classic diabetes-causing drug, which has a nitroso group that can produce NO, a toxic substance in pancreatic β cells. NO participates in many free radical cascade reactions, induces apoptosis of pancreatic β cells, reduces cell metabolism and insulin secretion. NIT-1 is a kind of islet β cell established in non-obese transgenic mice, which is widely used in the screening of hypoglycemic drugs. In this experiment, streptozotocin was used to act on NIT-L1 islet β cells, which can induce damage to NIT-L1 islet β cells, and its pathological mechanism is similar to that of type I diabetes.

[0038] Well-growing logarithmic phase NIT-L1 islet β cells were inoculated in 96-well plates, and after 24 hours of attachment, they were divided into 10 groups, blank group, astragaloside B (3uM), astragaloside B (10uM), astragaloside B ...

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PUM

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Abstract

The invention discloses the application of vincetoxicoside B in the preparation of anti-diabetic drugs. The invention provides a novel choice and idea for the existing anti-diabetic drugs, widens the selecting field of the anti-diabetic drugs and contributes to the development of the technical field; the applied vincetoxicoside B of the invention is proved to have remarkable anti-diabetic effect; and the invention is selected from the extract of natural drugs having specific chemical structure, therefore, the feeding is quantifiable in the preparation and the invention is applicable to the preparation of drugs in modern forms.

Description

technical field [0001] The present invention relates to a new application of astragaloside B, in particular to the application of astragaloside B in the preparation of antidiabetic drugs. Background technique [0002] Diabetes mellitus (diabetes mellitus) is one of the most common chronic diseases today, and type 2 diabetes (Type II diabetes mellitus, also known as non-insulin-dependent diabetes mellitus, NIDDM) accounts for more than 90% of diabetic patients. Diabetes is a growing problem in both developed and developing countries, with serious and costly consequences including blindness, heart disease and kidney disease. It is estimated that from 2000 to 2050, the number of people with diabetes worldwide will increase by 165%. According to the statistics of the International Diabetes Federation, 4.3% of the population in China suffers from diabetes, and the number of patients will exceed 50 million in the next 20 years. Diabetes is the second killer of modern diseases. I...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10
Inventor 苏薇薇王永刚李沛波彭维丁林伟吴忠
Owner SUN YAT SEN UNIV
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