Non-oral preparation of kudzuvine root total aglycon, preparation method and application thereof

A total aglycon, non-oral technology, applied in the field of Pueraria aglycone extract, can solve the problems of total aglycon effect and application blank, total aglycon system research, ignoring Pueraria total aglycon research and other problems

Inactive Publication Date: 2009-09-02
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But existing technology all ignores the research to total aglycon of puerariae root, although Weng Hongbo etc. are in " the protective action and mechanism of daidzein of puerarin root to cerebral ischemia " (" Chinese Pharmacology Bulletin ", 1999, the 15th Volume 6 Issue), Han Wenquan conducted preliminary research on daidzein in the literature such as "Research and Development of Daidzein" ("Food and Drugs", 2006, Volume 8 Issue 5), but only for A single component of daidzein has been discovered, but no systematic research has been conducted on the total aglycons contained in kudzu root, so the effect and application of total aglycons have always been in a blank state

Method used

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  • Non-oral preparation of kudzuvine root total aglycon, preparation method and application thereof
  • Non-oral preparation of kudzuvine root total aglycon, preparation method and application thereof
  • Non-oral preparation of kudzuvine root total aglycon, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] Take 50 g of total aglycones of Pueraria radiata, add 5 g of poloxamer, 600 to 20 g of polyethylene glycol, and add 4000 to 500 g of polyethylene glycol, heat and melt, grind and mix to make 1000 suppositories.

Embodiment 2

[0145] Take carbomer 5g, add water to swell for 24 hours, add triethanolamine to adjust the pH to 8, stir well, add 120g of puerarin total aglycone, 30g of total aglycone in blood flow, 12.5g of azone, 5g of propylene glycol, and add water to 500g , vibrating mill ultrafine pulverization for 50 minutes to make a gel.

Embodiment 3

[0147] Take 100 g of total aglycones of Pueraria root, add 5 g of lecithin, 5 g of propylene glycol, 5 g of eucalyptus oil, and 5 g of azone, and add lanolin to 200 g, ultrafinely pulverize with a vibrating mill for 60 minutes, pack separately, and make an ointment.

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Abstract

The invention discloses a non-oral preparation of kudzuvine root total aglycon, a preparation method and an application thereof, pertaining to the field of traditional Chinese medicine. Total glycosides extracted from kudzuvine roots are hydrolyzed to obtain total aglycon which is then added with special auxiliary materials for preparing a highly efficient preparation, thereby greatly increasing the bioavailability of the kudzuvine root total aglycon. The preparation has significant curative effects in the treatment of cardiovascular diseases, hyperpiesis, cerebral thrombosis, headache, diabetes, climacteric syndrome and tumor.

Description

technical field [0001] The invention relates to an extract of Pueraria radicis of traditional Chinese medicine, in particular to an extract of total aglycones of Pueraria radicis, and the medicinal use of the extract. It belongs to the field of traditional Chinese medicine. Background technique [0002] Pueraria lobata is the dry root of Pueraria labata (Willd.) Ohwi, a leguminous plant. Puerarin contains many flavonoids, such as puerarin, daidzin, 4,7-diglucodididin, and 3'methoxypuerarin , 7-xylose-puerarin, daidzein, etc., most of which exist in the form of glycosides. The total flavonoid glycosides in Pueraria lobata have good curative effect in the treatment of cardiovascular diseases, hypertension, cerebral thrombosis, headache, diabetes, menopausal syndrome and tumors. [0003] In literature reports, Li Qifan et al. in "Extraction and Purification of Medicinal Components from Pueraria Radix—Total Flavonoids" ("Anhui Agricultural Science", 2007, Vol. ("Pharmacology ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K31/352A61K9/00A61K9/02A61K9/06A61K9/70A61K47/44A61K47/34A61K47/24A61K47/22A61P3/10A61P7/02A61P9/00A61P9/12A61P15/12A61P25/04A61P35/00A61K125/00A61K47/10
Inventor 孙志强贾世伟
Owner 北京凯瑞创新医药科技有限公司
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