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Persimmon leaf extract preparation, preparing method thereof and application thereof

A persimmon leaf extract and preparation technology, which is applied in the field of persimmon leaf extract preparation and its preparation, can solve the problems of affecting absorption and bioavailability, long dissolution time, low dissolution rate, etc., and achieve good bioavailability, disintegration Reduced solution time and ideal friability

Active Publication Date: 2010-06-23
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because persimmon leaf extract is a traditional Chinese medicine extract with high viscosity, poor disintegration, and easy moisture absorption, its preparation generally has defects such as long dissolution time and low dissolution rate, which affect its absorption and bioavailability.

Method used

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  • Persimmon leaf extract preparation, preparing method thereof and application thereof
  • Persimmon leaf extract preparation, preparing method thereof and application thereof
  • Persimmon leaf extract preparation, preparing method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1, persimmon leaf extract tablet prescription

[0019] In this example, various formulations of different persimmon leaf extract tablets (250,000 tablets were prepared) were compared. The specific prescriptions are as follows:

[0020] Prescription 1

[0021] Dry paste powder of persimmon leaf extract (contains about 20% starch) 36kg

[0022] Dextrin 23kg

[0023] Starch 23kg

[0024] Crospovidone 9kg

[0025] Sodium carboxymethyl starch 6kg

[0026] Tween-80 0.5kg

[0027] Other 2.5kg

[0028] Prescription 2

[0029] Dry paste powder of persimmon leaf extract (contains about 20% starch) 36kg

[0030] Starch 35kg

[0031] Mannitol 10kg

[0032] Crospovidone 10kg

[0033] Sodium carboxymethyl starch 6kg

[0034] Tween-80 0.5kg

[0035] Other 2.5kg

[0036] Prescription 3

[0037] Dry paste powder of persimmon leaf extract (contains about 20% starch) 36kg

[0038] Powdered sugar 26kg

[0039] Starch 20kg

[0040] Starch slurry 10kg

[0041...

Embodiment 2

[0073] The preparation method of the persimmon leaf extract tablet of embodiment 2, embodiment 1

[0074] This example is the preparation method of the persimmon leaf extract tablet provided by the present invention, which is described in detail as follows.

[0075] 1) Preparation of persimmon leaf extract tablet: take persimmon leaf extract dry cream powder 36kg, starch 23kg, dextrin 23kg, crospovidone 9kg, carboxymethyl starch sodium 6kg, Tween-80 0.5kg, Polyvinylpyrrolidone K302kg, magnesium stearate 1kg. Granules made by wet method, compressed into tablets, coated with film, and made into 250,000 tablets.

[0076] Measure the following indicators of this persimmon leaf extract tablet: hardness (average 5.5KN is excellent), tablet weight (0.40g moderate, containing persimmon leaf extract 100mg / tablet), friability is qualified, and the disintegration time limit is 8 minute.

[0077] 2) Preparation of persimmon leaf extract tablet: take persimmon leaf extract dry cream p...

Embodiment 3

[0079] The performance measurement of the persimmon leaf extract tablet of embodiment 3, embodiment 1

[0080] For the persimmon leaf extract tablet prepared according to prescription 1 in Example 1, the performance of the tablet was tested at a specification of 100 mg / tablet, including disintegration time limit, friability, content and dissolution rate, as detailed below.

[0081] 1. Disintegration time limit inspection

[0082] Carried out with reference to the inspection method of the disintegration time limit of Appendix XII A of the 2005 edition of the Chinese Pharmacopoeia.

[0083] Measurement results: the disintegration time limit is 6-8 minutes, and a uniform suspension is formed. The currently commercially available Naoxinqing tablets (purchased from Guangzhou Baiyunshan Hutchison Whampoa Traditional Chinese Medicine Co., Ltd.) generally have a disintegration time limit of 14 to 20 minutes.

[0084] 2. Friability inspection

[0085] Carry out with reference to C...

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Abstract

The present invention provides persimmon leaf extract preparation, a preparing method thereof and application thereof. The persimmon leaf extract preparation comprises the following components: persimmon leaf extract dry paste of 20% to 50 %, dextrine of 10 % to 30%, starch of 20% to 40%, polyvinylpolypyrrolidone of 1% to 10%, sodium carboxymethyl starch of 1% to 10 % and Tween-800 of 1 % to 10%.In the preparing method, the persimmon leaf extract dry paste is mixed with various accessories, which can be pelletized by a wet method (water or ethanol with certain concentration is used as a wetting agent) to be preformed into tablet; or the persimmon leaf extract dry paste is mixed with various accessories to be directly preformed into the tablet in a dry method. The persimmon leaf extract preparation has better disintegration performance, and the disintegration time is shortened; even suspension can be formed; the drug biologic use degree is improved; and the persimmon leaf extract preparation is suitable for curing coronary heart disease, angina, cerebral arteriosclerosis, transient ischemic attacks, cerebral thrombosis sequela, senile dementia and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular, the invention relates to a persimmon leaf extract preparation and its preparation method and application. Background technique [0002] Persimmon leaves are bitter in taste and cold in nature, and have the effects of relieving asthma, quenching thirst and promoting body fluid, and treating sores. Modern medical research shows that persimmon leaf extract contains flavonoids, tannins, phenols, coumarins, organic acids, carotene and other chemical components, and has a wide range of physiological activities, which can effectively improve cardiovascular and cerebrovascular functions, Increase coronary flow, lower blood pressure and blood lipids, and prevent neurological degeneration. It is suitable for the treatment of various cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, cerebral arteriosclerosis, transient ischemic attack, sequelae of ...

Claims

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Application Information

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IPC IPC(8): A61K36/44A61K47/38A61K47/36A61K47/26A61K47/12A61P9/10A61P7/02A61P25/08A61K127/00
Inventor 林青李楚源刘兴华肖晓丽
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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