High imbibition dissoluble drug release external contraceptive membrane

Abstract

The invention discloses a high imbibition dissoluble drug release external contraceptive membrane, which is prepared by the following raw materials of 0.06-1.2 parts of nonoxynol-9, 2-6 parts of super absorbent resin, 60-90 parts of polyvinyl alcohol, 6-10 parts of polypropylene glycol, 4-8 parts of vegetable oil and the like. The contraceptive membrane made by the use of the composition of materials has elasticity, toughness and crisp property, effectively obstructs the sperms in semen and quickly absorbs semen and kills sperms. After the contraceptive membrane made from the materials is putin vagina, sexual intercourse can start immediately without waiting; and the contraceptive membrane can remain the shape of a crisp septum for up to 4h when not encountering semen, thus avoiding the loss of sperm killing drugs as well as the disappearance of local acrimony. The vegetable oil and vagina mucosa used in the invention have good compatibility and can remove the stimulation effect of the nonoxynol-9 on skin mucosa. The product can absorb the residual liquid and secretions as well as bacteria, viruses and other causative organisms in the secretions after vaginal douche and the treatment of an ozone gynaecology therapeutic instrument, also has killing effect, prolongs sterilization time and improves treating effect.

Description

technical field [0001] The invention relates to a contraceptive film-forming material composition, in particular to an external contraceptive film with high liquid absorption and soluble drug release. Background technique [0002] Currently commonly used external contraceptives are products such as nonoxynol suppository, nonoxynol film and nonoxynol gel. After more than 30 years of clinical observation of contraceptive drugs for external use, it is found that the contraceptive effective rate is only 78-86%. Among them, the nonoxynol suppository and nonoxynol film have the disadvantage that it takes 5-10 minutes to have sexual intercourse after being inserted into the vagina. If the method of use is not mastered properly, the contraceptive effect will be affected. Another shortcoming of contraceptives for external use is the presence of local irritation, about 70% of people will experience adverse reactions such as local burning sensation, increased secretions and genital it...

AI Technical Summary

Problems solved by technology

Among them, the nonoxynol suppository and nonoxynol film have the disadvantage that it takes 5-10 minutes to have sexual intercourse after being inserted into the vagina. If the method of use is not well mastered, the contraceptive effect will be affected

Another disadvantage of external contraceptives is the presence of local irritation, about 70% of people will experience adverse reactions such as local burning sensation, increased secretions, and genital itching after use

At present, although various manufacturers and scientific researchers have improved the dosage forms of contraceptives for external use, they still have not overcome the above shortcomings.

The existence of above-mentioned shortcoming has had a strong impact on the use of external contraceptives