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Dynamic scanning automatic microscope and method

A dynamic scanning and microscopy technology, applied in microscopes, instruments, computing, etc., can solve the problem of long total time

Inactive Publication Date: 2009-10-07
IKONISYS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total time required to perform a single diagnosis may be unacceptably long

Method used

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  • Dynamic scanning automatic microscope and method
  • Dynamic scanning automatic microscope and method
  • Dynamic scanning automatic microscope and method

Examples

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Embodiment Construction

[0018] In one embodiment, an automated microscope system includes a slide positioning stage and interchangeable elements configured to allow continuous loop insertion into the optical path. These interchangeable elements configured on the actuator driven carousel may include filters, lenses, light barriers, illumination sources, and / or imaging devices. In one embodiment, reflective (epi) and transmissive (epo) illumination sources may be recycled to obtain reflected and transmitted images. The positions of the stage and each interchangeable element carousel are determined by respective actuators controlled by feedback loops. Each instantaneous position is precisely telemetered and communicated to the synchronized controller.

[0019] During operation, sample slides are loaded onto the stage. The X-axis and Y-axis linear actuators scan the position of the slide in the X and Y-axis directions at a constant speed, so that the entire sample area passes through the field of view ...

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Abstract

An automatic microscope is disclosed which incorporates dynamic scanning of the microscope slide and other interchangeable optical path components.

Description

[0001] Cross References to Related Applications [0002] This application claims priority from US Provisional Application No. 60 / 821,552. All references cited in this application and the contents of their references which are suitable for teaching additional or alternative details, features and / or technical background are hereby incorporated by reference. Background technique [0003] Automated microscopy techniques are finding applications in the medical field. For example, analysis of body tissue using fluorescence in-situ hybridization (FISH) has become an effective means for diagnosing chromosomal abnormalities. The hybridized or bonded label recognizes the target site on the DNA strand by emitting fluorescence at a specific wavelength when stimulated by illuminating radiation. These fluorescent spots can be detected under a microscope. This analysis is accomplished by counting FISH spots and determining the distribution of FISH spots of different colors. [0004] Typi...

Claims

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Application Information

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IPC IPC(8): G02B21/26
CPCG02B21/24G02B21/008G02B21/002G02B21/26G06F18/00
Inventor T·P·塔法斯Y·朱
Owner IKONISYS INC
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