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Calcitriol dripping pill and preparation method thereof

A technology of calcitriol and dripping pills, which is applied in pill delivery, bone diseases, and pharmaceutical formulations. It can solve problems such as monotonous dosage forms, poor stability of ointments and tablets, and achieve increased stability, drug safety, and fast onset effect

Active Publication Date: 2011-07-20
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a special species, calcitriol has a relatively monotonous dosage form. Because it is sensitive to light and air, the stability of ointment and tablet is not good.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Now with several groups of specific examples, the preparation method of the calcitriol dropping pills of the present invention will be further described.

[0023] [recipe selection]

[0024] 1. Drug raw material: calcitriol

[0025] 2. Single matrix: selected from polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac and other carriers;

[0026] 3. Combination matrix: take g or kg as the unit, by weight, choose polyethylene glycol, polyoxyl 40 stearate, sodium carboxymethyl starch, beta-cyclodextrin, Tween-80 and other carriers carry out combination tests;

[0027] 3.1 The combination of two different substrates: in g or kg, by weight, take 1 part of polyoxyl 40 stearate or beta cyclodextrin or sodium carboxymethyl starch or Tween-80, Combined with 1-10 parts o...

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PUM

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Abstract

The invention discloses a drug for treating osteoporosis, and particularly relates to an oral dripping pill preparation prepared by adopting calcitriol as raw material. The invention aims at making upthe defects that the existing preparation formulation is little and the drug is not stable and providing an oral dripping pill preparation with high bioavailability, fast drug releasing, fast effect,high drug content, good stability of drug, convenient taking and no pollution in production. The calcitriol dripping pill adopts calcitriol as raw material and is prepared with carrier which is pharmaceutically acceptable and used as matrix.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a calcitriol drop pill for treating osteoporosis and a preparation method thereof Background technique [0002] Calcitriol (Calcitriol) other names: 1a, 25-dihydroxyvitamin D3, 1a, Luo Calcium, irrigated pure, 1a, 25 --- DihydroxyvitaminD3, developed by the Swiss company Roche, first listed in 1982 June (Switzerland). It was first registered in China in 1988, and the registration number is X880091. The product is white crystalline powder, sensitive to light and air. Slightly soluble in methanol, ethanol, ethyl acetate. Tm is 111-115°C. This product is one of the most important active metabolites of vitamin 1a, 25D3. This metabolite is normally formed in the kidney. In recent years, it has been found that calcitriol can also be produced outside the kidney. It has been confirmed that placenta, monocytes, macrophages, tumor cell supernatants, lymph nodes and kerat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/593A61K47/10A61K47/14A61K47/34A61K47/36A61K47/40A61K47/42A61K47/46A61P19/10A61K47/12A61K47/20A61K47/26
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD
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