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Pharmaceutical composition containing prasugrel and carbazochrome sodium sulfonate

A technology of sodium carbosulfonate and its composition, which is applied in the field of new pharmaceutical compositions, can solve problems such as reducing patient compliance and rebounding of cardiovascular events, and achieve the effect of inhibiting platelet aggregation

Active Publication Date: 2011-04-13
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the drug induces an increased risk of bleeding, even if the bleeding is not severe, it will significantly reduce the patient's compliance. The risk of reduced compliance is important in antiplatelet agents, which may lead to rebound cardiovascular events

Method used

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  • Pharmaceutical composition containing prasugrel and carbazochrome sodium sulfonate
  • Pharmaceutical composition containing prasugrel and carbazochrome sodium sulfonate
  • Pharmaceutical composition containing prasugrel and carbazochrome sodium sulfonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 common tablet

[0016] Sodium carbosulfonate 50g

[0017] Prasugrel Maleate 5g

[0018] Microcrystalline Cellulose 250g

[0019] Lactose 20g

[0020] 10% starch slurry appropriate amount

[0021] Magnesium stearate 0.8g

[0022] Preparation process: Weigh the prescribed amount of sodium carbosulfonate, prasugrel maleate, microcrystalline cellulose, and lactose and mix evenly.

[0023] In addition, add an appropriate amount of 10% starch slurry to the mixed powder, mix evenly, make soft material, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of the dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 2

[0024] Embodiment 2 common tablet

[0025] Sodium carbosulfonate 10g

[0026] Prasugrel HCl 20g

[0027] Starch 140g

[0028] Dextrin 120g

[0029] 50% ethanol appropriate amount

[0030] Magnesium Stearate 1.0g

[0031] Preparation process: Weigh the prescription amount of sodium carbosulfonate, prasugrel hydrochloride, starch and dextrin and mix evenly. In addition, add an appropriate amount of 50% ethanol to the mixed powder, mix evenly, make soft material, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of the dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 3

[0032] Embodiment 3 Dispersible tablets

[0033] Sodium carbosulfonate 5g

[0034] Prasugrel 25g

[0035] Croscarmellose Sodium 10g

[0036] Microcrystalline Cellulose 150g

[0037] Polyvinylpyrrolidone 5.5g

[0038] 5% PVP60% ethanol solution appropriate amount

[0039] Micronized silica gel 5g

[0040] Preparation process: Weigh carbosulfonate sodium and prasugrel according to the prescription, use microcrystalline cellulose as filler, cross-linked carmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60% alcohol solution It is used as binder, and micronized silica gel is used as flow aid. It is granulated in one step in a fluidized bed, and then compressed into tablets.

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Abstract

The invention provides a pharmaceutical composition containing active carbazochrome sodium sulfonate and prasugrel or the pharmacologically acceptable salt thereof. The invention aims to invent a moreeffective and low adverse-reaction method for curing thrombotic diseases by using the combined medication of the carbazochrome sodium sulfonate and the prasugrel. After conscientious trail of the patent applicant for many times, the effect of applying the carbazochrome sodium sulfonate to inhibit thrombosis in a combined manner is discovered unexpected in the process of applying the prasugrel tocure the thrombotic diseases, the anticoagulant effect of the prasugrel is not abated but increased, and the very good synergistic effects are achieved after the combination of the carbazochrome sodium sulfonate and the prasugrel, therefore, the risk of bleeding is greatly reduced when the advantages of good anticoagulant activity and fast effect of the prasugrel during the antiplatelet aggregation are fully exerted, the risk of bleeding caused by the prasugrel is effectively reduced and the compliance of patients is enhanced.

Description

technical field [0001] The invention belongs to a new pharmaceutical composition, in particular to a pharmaceutical composition comprising prasugrel or a pharmacologically acceptable salt thereof and sodium carbosulfonate as active components. Background technique [0002] Sodium carbosulfonate (Xinanluoxue) is a new generation of vascular hemostatic drug. It is a derivative of Anluoxue. The sodium sulfonate group is introduced into the molecular structure to overcome the low solubility of Anluoxue. It must be prepared by salicylic acid. Disadvantages of solubilization, and avoid the salicylic acid reaction that may occur after long-term repeated application. Compared with Anluoxue (adrenochrome hydrazone), sodium carbosulfonate has high water solubility, multiple routes of administration (oral, intramuscular or intravenous injection, intravenous infusion, endoscopic spraying, etc.), and has a fast hemostatic effect. Less adverse reactions, wide range of application, etc., ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4365A61K31/404A61P7/02
Inventor 赵志全姚景春
Owner LUNAN PHARMA GROUP CORPORATION
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