Method for preparing nuclear medicine diagnostic reagent oxygen-18 water and device thereof

Abstract

The invention relates to a method for preparing nuclear medicine diagnostic reagent oxygen-18 water and a device thereof. The method comprises the steps of: utilizing an oxygen isotope water industrial rectifying separation device to obtain deuterium oxygen 18 doubly-labelled water as material; carrying out steps of electrolysis, purification and filtering to obtain high-purity deuterium and high-purity oxygen-18 gas; adopting a high-temperature platinum mesh to carry out catalyzing so as to lead the high-purity deuterium to react with the high-purity oxygen-18 gas at high temperature to generate deuterium water; and adopting the high-temperature platinum mesh to carry out catalyzing to lead the high-purity oxygen-18 gas to directly react with high-purity hydrogen to obtain the highly-purified oxygen-18 water adopted as the diagnostic reagent of nuclear medicine. Compared with the prior art, the invention which not only can make full use of the deuterium oxygen 18 doubly-labelled water to prepare the nuclear medicine diagnostic reagent oxygen-18 water and utilize by-product deuterium to prepare deuterium water but also can reduce process steps, enhance quality and yielding of oxygen-18 water of nuclear medicine and reduce product cost really has simple process and better effect.

Description

technical field [0001] The invention belongs to the technical field of preparation of stable isotope reagents, and in particular relates to a preparation method and device for oxygen 18 water, a nuclear medicine diagnostic reagent. Background technique [0002] Oxygen in nature has three stable isotopes, their mass numbers are 16, 17, and 18, and their abundances in natural water are 99.76%, 0.04%, and 0.2% atoms respectively. Among them, 16O is common oxygen element, and 18O and 17O are heavy oxygen elements. Oxygen 18 water is a hydride of the oxygen 18 isotope, which has the same properties as ordinary water (H 2 16 O) The same physicochemical properties. [0003] Oxygen 18 isotopes can be bombarded by medical cyclotrons to obtain fluorine 18 ions, and its labeled positron imaging drug 18F-FDG is mainly used in nuclear medicine positron emission computed tomography (Positron Emission Computed Tomography, PET), so oxygen 18 Water is widely demanded as a nuclear medicin...

AI Technical Summary

Problems solved by technology

The main disadvantages are: 1. The deuterium gas is directly emptied without utilization

In fact, deuterium gas can be used to prepare heavy water and deuterated reagents, which also has high economic value; second, the electrolysis process will cause serious loss of double-labeled water raw materials, and the yield of product oxygen 18 is low; third, the electrolysis process will have A small amount of deuterium leaks into the oxygen 18 gas, and enters the oxygen 18 water product in the subsequent catalytic reaction process, which ultimately affects the quality of the product; 4. The oxygen 18 gas produced by electrolysis will entrain a small amount of double-labeled water, which will eventually affect the quality of the product. 5. In order to be used as a diagnostic reagent in nuclear medicine, oxygen-18 water must go through refining and purification processes such as removing organic matter, removing inorganic matter, removing bacteria, and removing heat sources. These processes are relatively complicated and lengthy, and will reduce the abundance of oxygen-18, Further reduce the yield of oxygen 18 water, affect product quality, and increase the production cost of nuclear medicine diagnostic reagent-oxygen 18 water

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