Method for preparing nuclear medicine diagnostic reagent oxygen-18 water and device thereof

A technology for diagnostic reagents and nuclear medicine, applied in the field of preparation of stable isotope reagents, can solve the problems of low yield of product oxygen 18, reduced yield of oxygen 18 water, running loss of double-standard water raw materials, etc., so as to improve the utilization value and reduce the The effect of running loss and reducing production cost

Active Publication Date: 2009-11-11
SHANGHAI RES INST OF CHEM IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main disadvantages are: 1. The deuterium gas is directly emptied without utilization
In fact, deuterium gas can be used to prepare heavy water and deuterated reagents, which also has high economic value; second, the electrolysis process will cause serious loss of double-labeled water raw materials, and the yield of product oxygen 18 is low; third, the electrolysis process will have A small amount of deuterium leaks into the oxygen 18 gas, and enters the oxygen 18 water product in the subsequent catalytic reaction process, which ultimately affects the quality of the product; 4. The oxygen 18 gas produced by el

Method used

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  • Method for preparing nuclear medicine diagnostic reagent oxygen-18 water and device thereof
  • Method for preparing nuclear medicine diagnostic reagent oxygen-18 water and device thereof
  • Method for preparing nuclear medicine diagnostic reagent oxygen-18 water and device thereof

Examples

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Example Embodiment

[0021] Example 1

[0022] Such as figure 2 Shown is the flow chart of the preparation method of oxygen 18 water, a diagnostic reagent for nuclear medicine of the present invention. The preparation method for the nuclear medicine diagnostic reagent-oxygen 18 water of the present invention first adds the deuterium oxygen 18 double standard water raw materials obtained by the industrial water rectification method to an electrolytic cell for electrolysis, and the deuterium gas obtained by the electrolysis is prepared into deuterium water through a catalytic reaction. The deuterium gas is used; the oxygen 18 gas obtained by electrolysis is firstly subjected to a catalytic purification process, and then a dry adsorption process is used to obtain high-purity oxygen 18 gas. The platinum wire mesh is used to directly catalytically react with high-purity hydrogen at high temperature to obtain the quality directly Qualified for nuclear medicine diagnostic reagent-oxygen 18 water.

[0023] S...

Example Embodiment

[0028] Example 2

[0029] See Figure 2~3 , A method for preparing oxygen 18 water as a diagnostic reagent for nuclear medicine. This method uses the deuterium 18 double-labeled water obtained by the oxygen isotope water rectification industrial separation device as a raw material, and first obtains high-purity deuterium through electrolysis, purification and purification. High-temperature platinum wire mesh catalyzes the high-purity deuterium gas and high-purity oxygen to react at high temperature to obtain heavy deuterium water. The high-temperature platinum wire mesh catalyzes the high-purity oxygen 18 gas and high-purity hydrogen gas to pass high temperature. The reaction directly obtains a highly purified reagent that can be used for nuclear medicine diagnosis-oxygen 18 water.

[0030] The above method is implemented using the following device. The device includes a deuterium-oxygen 18 double-labeled water electrolysis cell 1, a raw material storage tank 2, a raw material stor...

Example Embodiment

[0032] Example 3

[0033] See Figure 2~3 , A method for preparing oxygen 18 water as a diagnostic reagent for nuclear medicine. This method uses the deuterium 18 double-labeled water obtained by the oxygen isotope water rectification industrial separation device as a raw material, and first obtains high-purity deuterium through electrolysis, purification and purification. High-temperature platinum wire mesh catalyzes the high-purity deuterium gas and high-purity oxygen to react at high temperature to obtain heavy deuterium water. The high-temperature platinum wire mesh catalyzes the high-purity oxygen 18 gas and high-purity hydrogen gas to pass high temperature. The reaction directly obtains a highly purified reagent that can be used for nuclear medicine diagnosis-oxygen 18 water.

[0034] The above method is implemented using the following device. The device includes a deuterium-oxygen 18 double-labeled water electrolysis cell 1, a raw material storage tank 2, a raw material stor...

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Abstract

The invention relates to a method for preparing nuclear medicine diagnostic reagent oxygen-18 water and a device thereof. The method comprises the steps of: utilizing an oxygen isotope water industrial rectifying separation device to obtain deuterium oxygen 18 doubly-labelled water as material; carrying out steps of electrolysis, purification and filtering to obtain high-purity deuterium and high-purity oxygen-18 gas; adopting a high-temperature platinum mesh to carry out catalyzing so as to lead the high-purity deuterium to react with the high-purity oxygen-18 gas at high temperature to generate deuterium water; and adopting the high-temperature platinum mesh to carry out catalyzing to lead the high-purity oxygen-18 gas to directly react with high-purity hydrogen to obtain the highly-purified oxygen-18 water adopted as the diagnostic reagent of nuclear medicine. Compared with the prior art, the invention which not only can make full use of the deuterium oxygen 18 doubly-labelled water to prepare the nuclear medicine diagnostic reagent oxygen-18 water and utilize by-product deuterium to prepare deuterium water but also can reduce process steps, enhance quality and yielding of oxygen-18 water of nuclear medicine and reduce product cost really has simple process and better effect.

Description

technical field [0001] The invention belongs to the technical field of preparation of stable isotope reagents, and in particular relates to a preparation method and device for oxygen 18 water, a nuclear medicine diagnostic reagent. Background technique [0002] Oxygen in nature has three stable isotopes, their mass numbers are 16, 17, and 18, and their abundances in natural water are 99.76%, 0.04%, and 0.2% atoms respectively. Among them, 16O is common oxygen element, and 18O and 17O are heavy oxygen elements. Oxygen 18 water is a hydride of the oxygen 18 isotope, which has the same properties as ordinary water (H 2 16 O) The same physicochemical properties. [0003] Oxygen 18 isotopes can be bombarded by medical cyclotrons to obtain fluorine 18 ions, and its labeled positron imaging drug 18F-FDG is mainly used in nuclear medicine positron emission computed tomography (Positron Emission Computed Tomography, PET), so oxygen 18 Water is widely demanded as a nuclear medicin...

Claims

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Application Information

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IPC IPC(8): C01B5/00C25B1/04
CPCY02E70/10Y02E60/366Y02E60/36
Inventor 肖斌李猷周建跃姜永悦刘严秦川江
Owner SHANGHAI RES INST OF CHEM IND
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