Fermented milk for improving and/or treating skin and method for producing the same
A technology for fermented milk and skin, which is applied to the methods of using bacteria, preparations for skin care, biochemical equipment and methods, etc., can solve the problems of manufacturing costs, increased manufacturing time, complicated management, and mixed bacteria, etc., and achieves safety. high sex effect
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[0094] The inventors of the present invention conducted an in vitro test in order to select lactic acid bacteria with high skin-improving effect and / or therapeutic effect from lactic acid bacteria having curd-forming ability and good production characteristics used in the preparation of fermented milk, and the results are as follows As described above, it was found that the skin improving effect and / or therapeutic effect of Streptococcus thermophilus OLS3059 was particularly high.
[0095] The skin improvement and / or therapeutic composition containing Streptococcus thermophilus OLS3059 (Streptococcus thermophilus OLS3059) and / or its culture of the present invention may further contain Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 and / or cultures thereof.
[0096] According to the experiments of the present inventors, it can be known that the combination of Streptococcus thermophilus OLS3059 (Streptococcus thermophilus OLS3059) and / or its culture, and Lactobacill...
Embodiment 1
[0135] (Verification of atopic dermatitis inhibitory effect by in vitro test)
[0136] 4-week-old NC / Nga female mice (Bred by Japan SLC Co., Ltd.) were bred, and then divided into the following four groups.
[0137] Group given distilled water (n=10)
[0138] Group administered with Streptococcus thermophilus OLS3059 (hereinafter also referred to as OLS3059. Isolated from Bulgaria Yogurt LB81 ((registered trademark) Meiji Dairy Co., Ltd.)) (n=10)
[0139] Group not inducing dermatitis (n=7)
[0140] The group administered with Lactobacillus rhamnosus ATCC 53103 (Lactobacillus rhamnosus ATCC53103) (hereinafter also referred to as ATCC 53103) (comparison control with the group administered with OLS3059) (n=10).
[0141] These were allowed to ingest feed (trade name: CRF-1, manufactured by Oriental Yeast Industry Co., Ltd.) and distilled water freely.
[0142] Here, ATCC 53103 is a lactic acid bacterium known to have an effect on atopic dermatitis.
[0143] The other 3 groups...
Embodiment 2
[0151] (Verification of atopic dermatitis inhibitory effect by in vitro test)
[0152] 4-week-old NC / Nga female mice (Bred by Japan SLC Co., Ltd.) were bred, and then divided into the following three groups.
[0153] Group given distilled water (n=4)
[0154] Group administered with Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 (hereinafter also referred to as OLL1073R-1) (n=6)
[0155] Group administered with Streptococcus thermophilus OLS3059 (Streptococcus thermophilus OLS3059. Isolated from Bulgaria Yogurt LB81 (manufactured by Meiji Dairy Co., Ltd.)) (n=5)
[0156] These were allowed to ingest feed (trade name: CRF-1, manufactured by Oriental Yeast Industry Co., Ltd.) and distilled water freely. The same experimental conditions as in Example 1 were set except that the induction period of dermatitis was set to 30 days.
[0157] Changes in dermatitis incidence scores are shown in image 3 . The incidence scores 13 days after the initiation of dermatitis in...
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