Thermal initiation spontaneous explosion type magnetically targeted micro-capsule and preparation method thereof

Abstract

The present invention relates to a thermal initiation spontaneous explosion type magnetically targeted micro-capsule, comprising a shell and an oil kernel coated in the shell; wherein the shell is mainly composed of poly (N-isopropyl acrylamide) and superparamagetism Fe3O4 nano particle; the oil kernel is fluid oil or fluid oil containing emulsifier or mixture of fluid oil and liposoluble substances or liquid liposoluble substances. The preparation method of the micro-capsule has the following steps: (1) preparing modified superparamagetism Fe3O4 magnetic fluid; (2) preparing intermediate phase, internal phase and external phase fluid; (3) respectively injecting the internal phase, intermediate phase and external phase fluid into an injection tube, a transition tube and a collection tube of a capillary microfluid device to form monodisperse oil / water / fat liquor, then leading the monodisperse oil / water / fat liquor into a reaction container containing drip and irradiating the monodisperse oil / water / fat liquor for at least 8min at N2 atmosphere with ultraviolet light and then carrying out polymerization reaction on the monodisperse oil / water / fat liquor for 0.5-1h at the constant temperature of 4-30 DEG C; and (4) carrying out separation and purification.

Description

technical field [0001] The invention belongs to the technical field of targeting microcarriers, in particular to a microcapsule carrier capable of carrying fat-soluble substances and a preparation method thereof. Background technique [0002] In recent years, a lot of research has focused on the design and manufacture of microcapsules with specific structures and functions. The reason is that microcapsules have great application potential in many fields, such as controlling the release of various substances, protecting Active substances, used as microreactors, etc. Especially in the field of medicine, the use of microcapsules as a drug delivery carrier for the treatment of some fatal diseases such as cancer plays an important role, because most anticancer drugs are highly toxic and can be absorbed by all cells indiscriminately, In order to reduce the side effects of such drugs on normal human cells, it is necessary to deliver anticancer drugs to tumor lesions for release, a...

AI Technical Summary

Problems solved by technology

[0003] It is understood that although a variety of microcapsule carriers have come out, the existing microcapsules have the following limitations: 1. Usually, they can only carry water-soluble drugs, so fat-soluble anticancer drugs such as paclitaxel cannot be transported through microcapsules. Due to the effect of drug concentration gradient inside and outside the carrier, there is always the dissolution and diffusion of drug molecules through the microcapsule shell, so in the process of drug delivery, drug leakage will inevitably occur

2. Since the drug is released through the microscopic channel of the microcapsule membrane, when the microcapsule carrier reaches the designated location, it will take a long time to release a sufficient amount of the drug to achieve the therapeutic effect due to the upper limit of the diffusion rate of the drug through the capsule membrane. Higher drug concentration required; 3. Due to the principle of diffusion release or the influence of microcapsule material and structure, the drug loaded in the microcapsule cannot be completely released, which reduces the utilization rate of the drug and may also cause unnecessary side effect

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