Thermal initiation spontaneous explosion type magnetically targeted micro-capsule and preparation method thereof

A heat-initiated and magnetic-targeted technology, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of incomplete drug release, reduced drug utilization, drug leakage, etc., to facilitate industrial production, complete release, The effect of improving the utilization rate

Inactive Publication Date: 2011-08-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It is understood that although a variety of microcapsule carriers have come out, the existing microcapsules have the following limitations: 1. Usually, they can only carry water-soluble drugs, so fat-soluble anticancer drugs such as paclitaxel cannot be transported through microcapsules. Due to the effect of drug concentration gradient inside and outside the carrier, there is always the dissolution and diffusion of drug molecules through the microcapsule shell, so in the process of drug delivery, drug leakage will inevitably occur
2. Since the drug is released through the microscopic channel of the microcapsule membrane, when the microcapsule carrier reaches the designated location, it will take a long time to release a sufficient amount of the drug to achieve the therapeutic effect due to the upper limit of the diffusion rate of the drug through the capsule membrane. Higher drug concentration required; 3. Due to the principle of diffusion release or the influence of microcapsule material and structure, the drug loaded in the microcapsule cannot be completely released, which reduces the utilization rate of the drug and may also cause unnecessary side effect

Method used

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  • Thermal initiation spontaneous explosion type magnetically targeted micro-capsule and preparation method thereof
  • Thermal initiation spontaneous explosion type magnetically targeted micro-capsule and preparation method thereof
  • Thermal initiation spontaneous explosion type magnetically targeted micro-capsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] In this example, the process steps for preparing thermally induced self-explosive magnetic targeting microcapsules are as follows:

[0044] (1) Superparamagnetic Fe 3 o 4 Nanoparticles and Modified Superparamagnetic Fe 3 o 4 Preparation of magnetic fluid

[0045] 4mL HCl, 0.0362mol FeCl 2 4H 2 O was dissolved in 20 mL deionized water to form Fe 2+ solution; 0.1mol FeCl 3 ·6H 2 O was dissolved in 100 mL deionized water to form Fe 3+ solution. Fe 3+ Solution 29mL, mix it with Fe 2+ solution mixed, and then to the above Fe 2+ / Fe 3+ Add deionized water to the mixed solution to make the volume of the mixed solution to 100mL. 2+ / Fe 3+ Add 40mL NH to the mixture 3 ·H 2 O, when the reaction solution turns black, about 4.7 grams of Fe are generated 3 o 4 Particles that will generate Fe 3 o 4 The particles were separated by a magnet and washed three times with deionized water, then added 90 mL of tetramethylammonium hydroxide aqueous solution with a concent...

Embodiment 2

[0062] In this example, heat-induced self-explosive magnetic targeting microcapsules loaded with fat-soluble substance Sudan Red were prepared, and the process steps were as follows:

[0063] (1) Superparamagnetic Fe 3 o 4 Nanoparticles and Modified Superparamagnetic Fe 3 o 4 Preparation of magnetic fluid

[0064] Superparamagnetic Fe 3 o 4 The preparation of nanoparticles is the same as in Example 1, and the modified superparamagnetic Fe 3 o4 The preparation of the magnetic fluid is the same as in Example 1.

[0065] (2) Preparation of intermediate phase, internal phase and external phase fluid

[0066] Preparation of mesophase fluid: 0.002mol monomer N-isopropylacrylamide, 0.00002mol N, N'-methylenebisacrylamide, 0.00002mol ammonium persulfate and 0.04 Add 4 mL of modified superparamagnetic Fe prepared by step (1) to 1 gram of Pluronic F127 3 o 4 In the magnetic fluid, the mesophase fluid is formed by mixing evenly;

[0067] The internal phase fluid is soybean oil...

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Abstract

The present invention relates to a thermal initiation spontaneous explosion type magnetically targeted micro-capsule, comprising a shell and an oil kernel coated in the shell; wherein the shell is mainly composed of poly (N-isopropyl acrylamide) and superparamagetism Fe3O4 nano particle; the oil kernel is fluid oil or fluid oil containing emulsifier or mixture of fluid oil and liposoluble substances or liquid liposoluble substances. The preparation method of the micro-capsule has the following steps: (1) preparing modified superparamagetism Fe3O4 magnetic fluid; (2) preparing intermediate phase, internal phase and external phase fluid; (3) respectively injecting the internal phase, intermediate phase and external phase fluid into an injection tube, a transition tube and a collection tube of a capillary microfluid device to form monodisperse oil / water / fat liquor, then leading the monodisperse oil / water / fat liquor into a reaction container containing drip and irradiating the monodisperse oil / water / fat liquor for at least 8min at N2 atmosphere with ultraviolet light and then carrying out polymerization reaction on the monodisperse oil / water / fat liquor for 0.5-1h at the constant temperature of 4-30 DEG C; and (4) carrying out separation and purification.

Description

technical field [0001] The invention belongs to the technical field of targeting microcarriers, in particular to a microcapsule carrier capable of carrying fat-soluble substances and a preparation method thereof. Background technique [0002] In recent years, a lot of research has focused on the design and manufacture of microcapsules with specific structures and functions. The reason is that microcapsules have great application potential in many fields, such as controlling the release of various substances, protecting Active substances, used as microreactors, etc. Especially in the field of medicine, the use of microcapsules as a drug delivery carrier for the treatment of some fatal diseases such as cancer plays an important role, because most anticancer drugs are highly toxic and can be absorbed by all cells indiscriminately, In order to reduce the side effects of such drugs on normal human cells, it is necessary to deliver anticancer drugs to tumor lesions for release, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/44A61K47/02A61K47/32A61K9/50
Inventor 汪伟褚良银刘丽巨晓洁谢锐
Owner SICHUAN UNIV
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