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Peptide compounds for treating refractory status epilepticus

A composition and drug technology, applied in the direction of drug combination, drug delivery, active ingredients of heterocyclic compounds, etc., can solve problems such as harmful effects and adverse reactions

Inactive Publication Date: 2010-01-27
UCB SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Effective AED combinations have been evaluated empirically in patients with refractory seizures; however, such evaluations are often accompanied by deleterious adverse effects (Warner et al., 1992; Luszczki et al., 2003)

Method used

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  • Peptide compounds for treating refractory status epilepticus
  • Peptide compounds for treating refractory status epilepticus
  • Peptide compounds for treating refractory status epilepticus

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0275] The purpose of this study was to study the relationship between LCM and conventional AEDs (phenytoin (PHT), carbamazepine (CBZ), valproate (VPA), lamotrigine (LTG), or LCM and Potential interactions between novel AEDs, topiramate (TPM), gabapentin (GBP) or levetiracetam (LEV)) in a mouse model of 6 Hz seizures. According to Deckers et al. (2000), isobolometric analysis for the evaluation of interactions between AEDs is considered the best method for detecting synergy, additivity or antagonism between AEDs in animal models of epilepsy. Adverse effects of such combinations were evaluated in the rotarod test.

[0276] animal

[0277] The experiments were carried out in adult male CBA mice (Odessa University) weighing 20 to 28 g. Mice were housed in group cages with free access to food and water, under standard laboratory conditions with a natural light-dark cycle. After 1 week of acclimatization to laboratory conditions, the animals were randomly assigned to test groups...

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Abstract

The present invention is directed to a pharmaceutical composition comprising a Compound (a) of a class of peptide Compounds and at least one further Compound (b) for the prevention, alleviation or / and treatment of epileptic seizures.

Description

[0001] This application claims US 60 / 813.967 of June 15, 2006, EP 06 021 470.7 of October 12, 2006, EP 06 021 469.9 of October 12, 2006 and EP 06 024 241.9 of November 22, 2006 priority, which is incorporated herein by reference. technical field [0002] The present invention relates to a pharmaceutical composition comprising a compound (a) of a class of peptide compounds and at least one additional compound (b) for the prevention, alleviation or / and treatment of epileptic seizures, wherein the composition is administered alone Compound (a) or (b) has a synergistic effect in preventing, alleviating or / and treating epileptic seizures. Background technique [0003] Certain peptides are known to exhibit central nervous system (CNS) activity and are useful in the treatment of epilepsy and other CNS disorders. These peptides are described in US Patent 5,378,729 and US Patent 5,773,475, which are hereby incorporated by reference. [0004] EP 1541138 relates to the use of a class...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P25/08A61K38/04A61K31/19A61K31/195A61K31/55A61K31/4166A61K31/35A61K31/53
CPCA61K38/04G01N33/6893A61K31/55A61P25/00A61P25/08A61P25/12A61K31/165A61K31/4015A61K9/0053A61K2300/00A61K31/5513A61K45/06
Inventor T·斯多尔
Owner UCB SA
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