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Application of Kadsura heteroclite (Roxb.) Craib polysaccharide of Guangdong province for preparing medicaments for preventing and/or treating senile dementia

A senile technology, applied in the application field of Guangdong hibiscus polysaccharide in the preparation of drugs for preventing and/or treating senile dementia, can solve the problems of high price, unsatisfactory medium and long-term effects, strong toxic and side effects, etc. , to achieve the effect of low effective dose, prevention of Alzheimer's disease, and low toxicity

Inactive Publication Date: 2011-11-09
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the existing drugs for the treatment of Alzheimer's disease have unsatisfactory medium and long-term effects, strong toxic and side effects, and high prices.

Method used

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  • Application of Kadsura heteroclite (Roxb.) Craib polysaccharide of Guangdong province for preparing medicaments for preventing and/or treating senile dementia
  • Application of Kadsura heteroclite (Roxb.) Craib polysaccharide of Guangdong province for preparing medicaments for preventing and/or treating senile dementia
  • Application of Kadsura heteroclite (Roxb.) Craib polysaccharide of Guangdong province for preparing medicaments for preventing and/or treating senile dementia

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of the total polysaccharides of Caulis Caulis in Guangdong: dry the medicinal material of Caulis Caulis, pulverize into fine powder, and reflux with 95% ethanol to degrease. After degreasing, the dregs are evaporated to dry the solvent, and water is added to reflux for extraction twice, and the extracts are combined and concentrated. Add 95% ethanol to the concentrated solution to a final concentration of 40% to remove starch, centrifuge, recover ethanol from the supernatant, precipitate with 80% alcohol in the concentrated solution, filter with suction, wash the precipitate with absolute ethanol, acetone, and petroleum ether, and dry at low temperature to obtain Sea Breeze Rattan Crude Polysaccharide.

Embodiment 2

[0037] The preparation of polysaccharide P1 of Caulis japonica: Dissolve the total polysaccharides of Caulis polysaccharides in distilled water, remove protein by Sevag method, precipitate with 80% alcohol twice, and use Sephadex G-100, Sephadex G-80 and Sephadex G-25 gel columns for precipitation respectively Eluted, and fractions were collected by peak, pooled, and lyophilized. The polysaccharide P1 of Caulis Caulis Caulis was obtained.

Embodiment 3

[0039] Preparation of Caulis polysaccharide P2: dissolve the total polysaccharides of Caulis polysaccharides in distilled water, filter with 100Kd ultrafiltration membrane, collect the filtrate, centrifuge in a 10Kd ultrafiltration centrifuge tube, collect the supernatant, and freeze-dry to obtain polysaccharides of Caulis polysaccharides P2.

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Abstract

The invention relates to the application of Kadsura heteroclite (Roxb.) Craib polysaccharide of Guangdong province for preparing medicaments for preventing and / or treating senile dementia. Kadsura heteroclite (Roxb.) Craib polysaccharide of Guangdong province is extracted and separated from plant Kadsura heteroclite (Roxb.) Craib of Guangdong province. The invention has the advantage that the purpose of the Kadsura heteroclite (Roxb.) Craib polysaccharide of Guangdong province for preparing medicaments for preventing and / or treating senile dementia is developed, with high safety and obvious treating effect. The Kadsura heteroclite (Roxb.) Craib polysaccharide can be taken for long term and can be prepared into various preparations, with abundant raw material source and low cost.

Description

technical field [0001] The invention relates to the application of Guangdong Caulis Caulis polysaccharide in pharmacy, in particular to the application of Guangdong Caulis Caulis polysaccharide in the preparation of drugs for preventing and / or treating senile dementia. Background technique [0002] Guangdong Haifengteng is the dry cane of Schisandraceae Schisandra plant heteromorphic southern Schisandra Kadsura heteroclita (Roxb.) Craib, which is clinically used for the treatment of rheumatic arthralgia, unfavorable joints, and tendon spasm. The research on the chemical constituents shows that Caulis Caulis contains lignans, triterpene acids, polysaccharides, volatile oils and other active ingredients, and there is no report on the medicinal use of Caulis polysaccharides. [0003] At present, there are 18 million people with senile dementia (that is, Alzheimer's disease) in the world, and it is estimated that in the next 25 years, senile dementia patients will reach 34 milli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P25/28
Inventor 罗焕敏李晓光肖飞
Owner JINAN UNIVERSITY
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