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Medicine for treating coronary heart disease and preparation method thereof

A technology for coronary heart disease and drugs, which is applied in the field of drug preparation, can solve problems such as depletion of yang qi, achieve anti-platelet aggregation, reduce the incidence of gastrointestinal adverse reactions and allergic reactions, and improve the effect of qi deficiency

Active Publication Date: 2012-08-08
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in long-term clinical use, we found that Tongguan Capsules have certain gastrointestinal adverse reactions and allergic reactions, and users may experience symptoms such as nausea, vomiting, abdominal pain, and urticaria. This is because the borneol in Tongguan Capsules is Synthetic borneol is industrially synthesized from camphor, turpentine and other extracts through chemical methods. It is pungent in nature and slightly cold in taste, and is easy to consume Yang Qi

Method used

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  • Medicine for treating coronary heart disease and preparation method thereof
  • Medicine for treating coronary heart disease and preparation method thereof
  • Medicine for treating coronary heart disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] a. Weigh 700 grams of Salvia miltiorrhiza and 300 grams of leech, wash, dry, crush, pass through a 120-mesh sieve, and obtain Salvia-Leech powder;

[0162] b. Weigh 1,000 grams of Astragalus, add 10L of water each time, decoct three times, boil each time for 1h, 45min and 45min, pass through a 60 mesh filter cloth while it is hot, combine the three filtrates, concentrate to moisture content ≤ 8%, and let cool until At room temperature, slowly add ethanol with a volume ratio of 60%, refrigerate and stand for 24h~48h, filter, and concentrate to a relative density of 1.10~1.20 at 20℃. Recover ethanol to obtain Astragalus extract;

[0163] c. Mix the Danshen-leech powder prepared in step a and the astragalus extract prepared in step b thoroughly, dry, crush, and pass through a 120-mesh sieve;

[0164] d. Add calcium carbonate and starch to the powder prepared in step c, mix them, and pack them into capsules, so that each capsule contains three kinds of native drugs in total 3.5 g,...

Embodiment 2

[0166] a. Weigh 800 grams of Astragalus and 800 grams of Salvia, add 16L of water each time, decoct three times, boil each time for 1h, 45min and 45min, pass through a 60-mesh filter cloth while it is hot, combine the three filtrates, and concentrate until the water content is ≤8% , Let cool to room temperature, slowly add 60% ethanol by volume, refrigerate and stand for 24h~48h, filter, and concentrate to 20℃ when the relative density is 1.10~1.20, recover ethanol to obtain extract;

[0167] b. Weigh 400 grams of leech, wash, dry, crush, pass through a 120-mesh sieve to obtain leech powder;

[0168] c. The extract prepared in step a and the leech powder prepared in step b are thoroughly mixed, dried, crushed, and passed through a 120-mesh sieve;

[0169] d. Add the powder prepared in step c to magnesium stearate, starch and other auxiliary materials to make soft materials, then make wet granules, then dry, sizing, and press, so that each tablet contains three native medicines. 3.5g...

Embodiment 3

[0171] a. Weigh 600g of Salvia miltiorrhiza, add 4.2kg of ethanol and heat to reflux for 1.5h, filter, add 2.1kg of dregs of 50% filtrate ethanol and heat to reflux for 1h, filter, combine the filtrate, and concentrate to 20℃ and the relative density is 1.10~1.20 , Recycle ethanol, and get salvia miltiorrhiza extract;

[0172] b. Weigh 1200g of astragalus and add it to the dregs of Shendan medicine, add 18L of water each time, decoc three times, boil for 1h, 45min and 45min each time, pass through a 60 mesh filter cloth while it is hot, combine the three filtrates, and concentrate to water content ≤8%, let cool to room temperature, slowly add 60% ethanol by volume, refrigerate and stand for 24h~48h, filter, and concentrate to 20℃ when the relative density is 1.10~1.20, recover the ethanol to obtain Astragalus extract;

[0173] c. Weigh 200g of leeches, wash, dry, smash, and pass through a 120-mesh sieve to obtain leech powder;

[0174] d. The extract prepared in steps a and b and th...

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Abstract

The invention discloses a new medicine for treating coronary heart disease, which comprises an active ingredient and excipient which can be accepted by pharmacy, wherein the active ingredient is prepared from raw materials according to the following parts by weight: 40-60% of astragalus root, 20-50% of danshen root, and 5-25% of leech. Discarding synthetic borneol in the existing Tongguan capsules, the medicine avoids the untoward reaction and anaphylaxis of the gastrointestinal tract which are caused by the synthetic borneol, and the curative effects are obviously enhanced.

Description

Technical field [0001] The invention relates to medical preparations containing raw materials, in particular to Chinese patent medicines prepared by using Chinese herbal medicines as raw materials. The invention also relates to a preparation method of the medicines. Background technique [0002] Coronary heart disease (CHD) is a major disease that endangers human health. According to the Global Disease Survey published in 1997, 50.5 million people die every year worldwide, of which 6.3 million are due to ischemic heart disease, making it the world's first cause of death . The gray series system model is used to predict that by 2010, the mortality rate of coronary heart disease in my country will reach 86.9 people per 100,000, that is to say, 1.2 million people will die of coronary heart disease nationwide. The morbidity and mortality of coronary heart disease are increasing year by year, bringing heavy medical and social burdens to the society. Therefore, the active and effectiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/10A61K35/62
Inventor 张敏州
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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