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Application of traditional Chinese medicine huanglian jiedu tang in preparing medicament for preventing and treating rheumatoid arthritis

A Coptidis Jiedu decoction, arthritis technology, applied in the direction of drug combination, antipyretic, anti-inflammatory agent, etc., to achieve the effect of overcoming poisoning effect and great clinical application value

Inactive Publication Date: 2010-02-24
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no specific therapy for rheumatoid arthritis so far, and it is still in the process of treating inflammation and sequelae.

Method used

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  • Application of traditional Chinese medicine huanglian jiedu tang in preparing medicament for preventing and treating rheumatoid arthritis
  • Application of traditional Chinese medicine huanglian jiedu tang in preparing medicament for preventing and treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] 1. Experimental materials

[0014] Drugs and Reagents

[0015] Chicken type II collagen (CII): Chondrex, Redmond, WA 98052, USA; Incomplete Freund's Adjuvant (IFA) Difco Laboratories, Detroit, MI; Phosphate buffered saline (PBS): self-prepared by our laboratory, in 800ml Dissolve 8g NaCl, 0.2g KCl, 1.44g Na in distilled water 2 HPO 4 and 0.24g KH 2 PO 4 . Use hydrochloric acid to adjust the pH to 7.4, add water to make up to 1L, and use after filter sterilization; DMSO dimethyl sulfoxide (Dimethyl sulfoxide, DMSO): a product of Sigma Company; 1640 medium: Jinuo Biomedical Technology Co., Ltd.; small Bovine serum: Minhai Biological Co., Ltd.; 96-well flat bottom plate, CORNING; 70 μm cell grinding filter, BD Falcon; 15ml, 50ml centrifuge tubes, BD Falcon; 0.22μm filter, Millipore; 1ml screw-top syringe, BD Company; Braun Tee, German Braun company; methotrexate tablets: Shanghai Pharmaceutical (Group) Co., Ltd. Xinyi Pharmaceutical General Factory (080605); Huanglia...

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Abstract

The invention provides an application of a traditional Chinese medicine huanglian jiedu decoction (comprising the Chinese medicine components of 9g of coptis chinensis, 6g of scutellaria baicalensis,6g of golden cypress and 9g of gardenia) in preparing a medicament for preventing and treating rheumatoid arthritis. When being used for animal pharmacodynamic test, the huanglian jiedu decoction is proved to have the functions of restraining the clinical pothogenesy of CIA (Collagen-Induced Arthritis), obviously restraining the severity and the morbidity of the CIA and having obvious protection function to the CIA. The huanglian jiedu decoction can reduce the contents of TNF-alpha, IL-17 and IFN-gamma in splenocyte supernatant and restrain the secretion of proinflammatory cytokine, i.e. TNF-alpha, IFN-gamma and IL-17, thereby playing a protecting role for the CIA disease. The invention provides a new traditional Chinese medicine for clinically treating rheumatoid arthritis, which can overcome the toxic and side effects of pharmaceutical chemicals, thereby bringing confidence for treating and achieving higher clinical application value.

Description

technical field [0001] The invention relates to traditional Chinese medicines, in particular to the application of Huanglian Jiedu Decoction in the preparation of medicines for preventing and treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoid Arthritis, RA) is a chronic systemic inflammatory disease of unknown etiology, with chronic, symmetrical, polysynovial arthritis and extra-articular lesions as the main clinical manifestations, belonging to autoimmune inflammatory diseases disease. The disease is prone to occur in small joints such as hands, wrists, and feet, and recurs in a symmetrical distribution. In the early stage, joints are red, swollen, hot, painful, and dysfunctional. In the late stage, joints may be stiff and deformed in varying degrees, accompanied by atrophy of bones and skeletal muscles, which is very easy to cause disability. From the perspective of pathological changes, rheumatoid arthritis is a disease that ma...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P19/02A61P19/04A61P29/00
Inventor 张卫东窦圣姗柳润辉刘晓华单磊苏娟沈云亨李慧梁徐希科刘心如
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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