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Anti-respiratory virus traditional Chinese medicine composite and preparation method and application thereof

A technology of anti-respiratory tract and composition, applied in the direction of antiviral agents, drug combinations, respiratory diseases, etc.

Active Publication Date: 2010-02-24
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still few reports on the effect sites and effect components of the compound, and the pharmacological effects and mechanisms of common respiratory viruses, which is far from the actual needs of the majority of patients.

Method used

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  • Anti-respiratory virus traditional Chinese medicine composite and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Example 1 Preparation of the volatile oil part of a traditional Chinese medicine compound:

[0103] Take 40g of licorice, 60g of ephedra, 100g of bitter almonds, 100g of pinellia, 200g of raw gypsum, 100g of fine tea, 60g of schisandra, a total of 660g, pulverized and placed in a 20000mL round-bottomed flask, add 10 times the mass of the medicinal material with purified water. After shaking and mixing, soak for 30 minutes;

[0104] Connect the volatile oil extractor and the reflux condenser. Add water from the upper end of the condenser tube to fill the scale part of the volatile oil tester and overflow into the flask. Slowly heat to 110℃ in an electric heating mantle, and keep it boiling for 8 hours, until the oil in the tester no longer increases, stop heating, leave it for a while, turn on the piston at the lower end of the tester, and slowly release the water until the upper end of the oil layer reaches Up to 5mm above the 0 line of the scale. Leave it for more than 1...

Embodiment 2

[0105] Example 2 A method for preparing compound volatile oil of traditional Chinese medicine, the steps are as follows:

[0106] Take 80g of licorice, 120g of ephedra, 200g of bitter almonds, 200g of pinellia, 400g of raw gypsum, 200g of fine tea, 120g of schisandra, and a total of 1320g of schisandra. After crushing, it is placed in a 20000mL round-bottomed flask. After shaking and mixing, soak for 30 minutes.

[0107] Connect the volatile oil extractor and the reflux condenser. Add water from the upper end of the condenser tube to fill the scale part of the volatile oil extractor until it overflows into the flask. Slowly heat to 110℃ in an electric heating mantle and keep boiling for 8 hours until the amount of oil in the extractor no longer increases. Stop heating, leave it for a while, turn on the piston at the bottom of the extractor, and slowly release the water until the upper end of the oil layer reaches Up to 5mm above the 0 line of the scale. Leave it for more than 1 ...

Embodiment 3

[0108] Example 3 A method for preparing the ethyl acetate part of a traditional Chinese medicine compound, the steps are as follows:

[0109] Take 40g of licorice, 60g of ephedra, 100g of bitter almonds, 100g of pinellia, 200g of raw gypsum, 100g of fine tea, 60g of schisandra, a total of 660g, pulverized and placed in a 20000mL round-bottomed flask, add 10 times the mass of the medicinal material with purified water. After shaking and mixing, soak for 30 minutes and connect the reflux condenser. Put it in an electric heating mantle and slowly heat it to 110°C to boil, and keep it boiling for 2 hours, stop heating, place it until the temperature of the flask is close to room temperature, and filter out the liquid medicine.

[0110] Then add 8 times the amount of purified water to the flask, shake and mix, soak for 30 minutes, and connect the reflux condenser. Put it in an electric heating mantle and slowly heat it to 110°C to boil, and keep it boiling for 1 hour, stop heating, pla...

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Abstract

The invention discloses a compound Chinese traditional medicine anti-respiratory virus effective component and a preparation method. The effective component is a compound Chinese traditional medicineessential oil component extracted by a steam distillation method and an ethyl acetate component extracted by an extraction method by utilizing crude drug which is prepared by liquorice, ephedra, bitter almonds, pinellia, gypsum, tea bust and schisandra in parts by weight. The invention has the advantages of simple preparation process, good ruggedness and low cost, and simultaneously maximally improves the extraction ratio of effective constituents in the compound. In-vitro tests show that the compound Chinese traditional medicine essential oil component and the ethyl acetate component providedby the invention have stronger anti-influenza A virus effect; the ethyl acetate component has stronger anti-respiratory syncytial virus effect; and the essential oil component has anti-influenza B virus effect. The compound Chinese traditional medicine essential oil component and the ethyl acetate component of the invention can be used for preparing new Chinese traditional medicine for preventingupper respiratory tract-related virus infection, and provide a new choice for preparing anti-respiratory virus medicine by utilizing Chinese traditional medicine compound with traditional treatment advantages.

Description

Technical field [0001] The invention relates to an anti-respiratory virus effective part of a traditional Chinese medicine compound and a preparation method thereof, and its application in the preparation and treatment of anti-respiratory virus, and belongs to the technical field of extraction and application of the effective part of a traditional Chinese medicine compound in the field of traditional Chinese medicine. Background technique [0002] Respiratory tract virus infection is a common clinical disease that can occur at all ages and has a variety of clinical manifestations. In severe cases, bronchiolitis and pneumonia can cause acute respiratory distress, heart failure, and even death. Respiratory viruses are susceptible to mutations, and some new diseases often occur, which pose a threat to human life, so they have especially attracted widespread attention. [0003] In the course of fighting diseases for more than two thousand years, Chinese medicine has summed up systemati...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P31/12A61P11/00A61K33/06
Inventor 范欣生俞晶华唐于平周玲段金廒
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE